One of the key challenges of regenerative medicine is to obtain mature differentiated cells for use in patients. This ambitious project will focus on human stem cells and differentiated stem cells to study chromatin state and the gene regulatory interactions underlying cellular identity.

As a postdoctoral researcher/PhD candidate you will use single-cell transcriptome analysis (single- cell RNA-seq) to distinguish subpopulations of cells with different identities and potential, and you will compare these transcriptomes to those of mature human cells. You will also obtain chromatin accessibility and epigenetic data (ATAC-seq, ChIP-seq) to examine gene-regulatory elements and to infer gene regulatory networks. You will use these data to predict and test key regulatory interactions with the aim of improving the maturation of differentiated stem cells. You will have the opportunity to develop novel ideas and work on an independent project that aligns with our research interests.

- a PhD (for postdoctoral researcher position) or a Master’s degree (for PhD candidate position) in molecular or cellular biology, molecular life sciences or a related field;
- experience in generation and analysis of next-generation sequencing or single-cell approaches;
- excellent communication skills in written and spoken English;
- strong analytical skills, a problem-solving and result-oriented attitude;
- the ability to work and interact with others in an energetic and supportive research environment.

duration of the contract: 2 years (postdoctoral researcher position) or 4 years (PhD candidate position). As a PhD candidate you will be appointed for an initial period of 18 months, after which your performance will be evaluated. If the evaluation is positive, the contract will be extended by 2.5 years
- you will be classified as a Postdoctoral Researcher, Level 4 or as a PhD candidate in the Dutch university job-ranking system (UFO).
depending on your profile, you will be appointed as a Postdoctoral Researcher (maximum gross monthly salary of €4,084, scale 10) or as a PhD Candidate (gross starting salary amounts to €2,222 per month, and will increase to €2,840 in the fourth year, P scale).
The Faculty of Science is an equal opportunity employer, committed to building a culturally diverse intellectual community, and as such encourages applications from women and minorities.

Radboud University

Strategically located in Europe, Radboud University is one of the leading academic communities in the Netherlands. A place with a personal touch, where top-flight education and research take place on a beautiful green campus in modern buildings with state-of-art facilities.

Faculty of Science

We are looking for a highly motivated and ambitious experimental biologist to join our research team in the Department of Molecular Developmental Biology, located at the Radboud Institute for Molecular Life Sciences (RIMLS), Faculty of Science (Radboud University, Nijmegen, Netherlands). We offer a first class international research environment in regulation of gene expression and epigenetics using state-of-the-art genomic and proteomic technologies and bioinformatics. We run next-generation sequencers, single-cell equipment, and mass spectrometers, and we accommodate a bioinformatics team and a local computational infrastructure.

No commercial propositions please.