Job Academic Medical Center (AMC) - PhD student Medical Biochemistry

Understanding the molecular and cellular basis of Angelman Syndrome

Angelman syndrome is a severe neurological disorder, affecting 1:12,000 children, that is caused by the loss of a functional copy of the maternal UBE3A gene. Although the UBE3A gene was identified 16 years ago to encode the ubiquitin protein ligase E6AP, little progress has been made that provides insight in its role in neuronal function.
This ZonMw funded project involves a strong multi-disciplinary effort from a neurobiology laboratory (Erasmus Medical Center) specialized in synaptic plasticity using mouse models, and from a biochemical laboratory (Academic Medical Center) specialized in protein-protein interaction and ubiquitination to get more insight in the most pressing questions concerning the mechanisms underlying Angelman syndrome.

The Department of Medical Biochemistry (AMC) is looking for a highly motivated PhD student who will be involved in the identification and validation of E6AP targets using in vitro and in vivo approaches. Candidates should have experience with protein biochemistry and molecular biology, plus a keen interest in protein ubiquitination.

Compensation will be according standard salary levels for PhD students starting with a salary from € 2086,- with a yearly growth to € 2673,- gross a month.

If you have any questions please contact Dr. B. Distel, e-mail: b.distel@amc.uva.nl or phone +31 20-5665127.