Job Biomedical Primate Research Centre (BPRC) - AiO/PhD student (Immunology/Cell Biology)

Your profile is that of a highly motivated young professional with an MSc. in (medical) biology, biochemistry or medicine. Expertise in cell culture and immunological, molecular biological and/or biochemical techniques is a prerequisite. You are energetic, curious and up-to-the-job and have an open mind with an intrinsic interest in problem solving.

Our research focuses on the role of brain tissue cells, such as astrocytes and microglia, in neuroinflammatory diseases as multiple sclerosis (MS). One of the hallmarks of MS pathology is the presence of activated microglia.

In this project, we will use in vitro primary cell cultures to study microglia activation via recently identified receptors of the innate immune system that can form inflammasomes. The involvement of inflammasomes in the development of MS lesions and of other neuroinflammatory disorders will be investigated by in situ analysis of human brain sections. In addition, we will search for mechanisms to halt microglia activation, with the ultimate aim to identify novel possibilities for therapeutical intervention.

Your profile is that of a highly motivated young professional with an MSc. in (medical) biology, biochemistry or medicine. Expertise in cell culture and immunological, molecular biological and/or biochemical techniques is a prerequisite. You are energetic, curious and up-to-the-job and have an open mind with an intrinsic interest in problem solving.

Hosting both basic scientific research as well as pre-clinical studies, the Biomedical Primate Research Centre (BPRC) provides an inspiring and dynamic working environment with academic standards while offering outstanding primary and secondary job conditions. In addition, we offer the opportunity to develop your professional capabilities and to benefit from external courses and academic collaborations without educational obligations.

The development of alternatives for the experimental use of animals in research has a central place within BPRC. The three R's for Replacement, Reduction and Refinement form the guideline along which the research within the Alternatives Unit is organized. This project contributes to both Reduction and Refinement of animal use.

For more information about this position see www.bprc.nl or contact the Alternatives Unit. Tel: +31 15 284 2722