The research will be carried out at the Netherlands Cancer Institute in Amsterdam the Netherlands (www.nki.nl) in the small molecule screening, drug innovation and chemical biology laboratory headed by Dr. Huib Ovaa research.nki.nl/Ovaalab/ The project aims to develop novel small molecule modulators...
27 January 2012 - max. 36.0 hours per week
Actin dynamics are key to migration of normal and cancer cells. We study how actin-based remodeling of the plasma membrane (i.e. protrusions and invaginations) occurs in crawling cells. At present, we focus on the function(s) and regulation of the Arp2/3 complex and mDia2, two crucial actin...
25 January 2012 - max. 36.0 hours per week
