Job The Netherlands Cancer Institute (NKI-AVL) - PhD Student

Tumor cell invasion involves the formation of specialized protrusions known as invadosomes. We recently discovered a crucial function for the cation channel TRPM7 in the formation of invadosomes. TRPM7 affects the cytoskeleton both by allowing Ca2+ influx into the cytoplasm, and by direct phosphorylation of myosins through its integral kinase domain. We have identified a large cytoskeletal complex around TRPM7 that contains many structural components of invadosomes, as well as signaling intermediates frequently upregulated during tumor progression. 

In this project we will focus on the role of TRPM7 as a 'master-regulator' of invadosomes. We will study how Ca2+ influx affects invadosome formation and function, and cell migration. A second focus will be the regulation of membrane PIP2, a messenger that affects many cytoskeletal proteins and that appears to function downstream of Ca2+ influx. This interdisciplinary project is funded by the Dutch Cancer Society (KWF). It fits in a long-term collaboration with dr. F.N. van Leeuwen at the Nijmegen Centre for Molecular Life Sciences, where a second PhD student will be employed who focuses on molecular aspects of the project.

We are looking for an enthusiastic and highly motivated PhD student with good communication skills in English. The candidate must have affinity for (advanced) microscopy techniques, and experience with cell biology, molecular biology and bioinformatics are a plus. Willingness to engage enthusiastically in the highly synergistic collaboration with the van Leeuwen lab is also essential.

The temporary employment will be for a period of 4 years. The gross monthly salary for a PhD student will range from € 2.354,- to € 2.899,- according to the PhD scales, depending on previous experience. The terms of employment will be in accordance with the CAO Ziekenhuizen (Collective Labor Agreement for Hospitals). The Netherlands Cancer Institute provides a very stimulating environment for graduate students. Apart from being a specialized institute and hospital with good working conditions and an excellent international atmosphere, the NKI-AVL has also been listed in the top 25 of ‘Best Employers’ in 2009.

For further information about the position please contact dr K.Jalink, tel. +31 20 512 1933 or e-mail: k.jalink@nki.nl