Vacature Department of Pediatrics, Pediatric Oncology - PhD student “Signal transduction pathways in pediatric medulloblastoma”

In brain tumors, brain cells mutate and show uncontrolled cell division. This neoplastic progression is the net-result of uncontrolled cell signaling through various protein kinase-mediated networks driving cell proliferation.
The aim of this project is to design an integrative map of activated signal transduction pathways in medulloblastoma to identify potential drugable targets. We will use the newest cellular techniques, including high throughput kinome and phosphoproteome profiling. We already used these techniques successfully in our Pediatric Oncology Research laboratory together with other national and international experts. The identified drugable targets will be further analyzed with standard cellular techniques.

- We are looking for a highly motivated candidate with a MSc degree in biology and a strong background in cellular biology and laboratory skills.
- The candidate has an interest in pediatric oncology and/or neuroscience. Affinity with bioinformatics is an advantage.
- The candidate should be flexible and accurate and have good social and communication skills.

The UMCG has a preventive Hepatitis B policy. You may be required to build up sufficient protection against Hepatitis B before you can be appointed. Vaccination is provided by the UMCG if necessary.

Estimated maximum salary per month: € 2.107,- (year 1) - € 2.700,- (year 4).
Employment basis: temporary for specific period.
Duration of the contract: four years.
Maximum hours per week: 36.
The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).

Working at the University Medical Center Groningen means working at the frontiers of knowledge. The Faculty of Medical Sciences offers researchers and students the opportunity to expand those frontiers, to develop their talents and together with others realize top quality achievements. The Pediatric Oncology Research Group is embedded in the program of the Northern Netherlands Oncology Center and collaborates with various (inter)national partners.

For our study ‘Identification of novel possible targets for pediatric medulloblastoma treatment by kinome profiling’, financed by a grant from KiKa (Stichting Kinderen Kankervrij) we have a position available for a PhD student. Information about KiKa: www.kika.nl

Dr. S.L.A. Plasschaert, M.D. PhD, Pediatric Oncologist
(050) 361 4213

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