Job Centre for Liver, Digestive and Metabolic Diseases - 非洲trypanosomes(SilicoTryp)的博士后的位置系统生物学

基于实验合伙人产生的信息，博士后研究员将建造将把redox和能量代谢和显著转导和基因表示结合起来的一个计算的模型。博士后研究员将与其他理论家和与实验合伙人协作。研究访问合作实验室将是工程的一部分。而且，博士后研究员将在SBC-EMA与同事协作，共有系统生物学专门技能理解各种各样的生物体的新陈代谢的规章。

我们正寻找一位极好，高度激进的博士后研究员，有专门技能在生物化学和/或基因表示的计算的模拟试验方面网络。博士后研究员应该用experimentalists有效地交流，在国外主要找到(爱丁堡，格拉斯哥，海德尔堡)。UMCG有一个预防的乙型肝炎政策。这表明在你可能被任命之前，你一定已经增加足够的预防乙型肝炎了。

-格罗宁根大学医学中心提供薪级制度每个月10/11的总额取决于经验。-位置将是3 年。-就业的条件遵循医疗中心(CAO-UMC)的集体劳动合同。

The University Medical Centre Groningen (UMCG) offers an excellent environment for research and training of scientific skills. Together with the Faculty of Mathematics and Natural Sciences of the University of Groningen, the UMCG has recently established a new Systems Biology Centre for Energy Metabolism and Ageing (SBS-EMA). The Systems Biology group headed by Dr. B.M. Bakker is part of the Centre for Liver, Digestive and Metabolic Diseases. Project description The SysMO-funded SilicoTryp project aims at developing a computational model of Trypanosoma brucei, the causative agent of African sleeping sickness, by combining cutting edge post-genomic technologies and advanced statistical, mathematical and bioinformatics approaches. The work is carried out in a close collaboration of several European research universities. The consortium consists of modellers, statisticians, biochemists and molecular cell biologists. Trypanosomes, blood-borne parasites transmitted by tsetse flies, are the causal agent of African sleeping sickness, a deadly disease for humans and cattle. A systems biology study of trypanosomes is particularly timely and has the potential to provide critical insights to the fundamental mechanisms controlling this parasite. Indeed, due to some of the trypanosome's unique biological characteristics and the wealth of information obtained in biomedical studies, this organism is particularly suited to a systems biological approach. Computational models of glucose metabolism as well as of the unusual gene-expression cascade of the organism have provided insight into the regulation of its physiology. The next step, which the SilicoTryp consortium will take, is to link glucose metabolism to the redox - trypanothione pathway and oxidative stress, as well as to signalling and gene expression. See also: Parasitology (2010) 137, 1333-41.

肝，消化和代谢疾病的巴巴拉·巴克(050)361 15 42Centre医生