Our group is interested in the mechanisms and functional consequences of post-translational protein modification by SUMO and ubiquitin. We integrate biochemistry, cell biology and proteomics approaches and use state-of-the art microscopes and mass spectrometers to obtain novel insights in SUMO- and ubiquitin signal transduction. We have previously shown that SUMO-2/3 are able to form chains in an ubiquitin-like manner. These chains then cooperate with the ubiquitin-proteasome system to regulate target protein degradation. Furthermore, we have recently developed innovative methodology to study SUMOylation and crosstalk between SUMOylation and ubiquitin in a cell-wide manner. You will investigate crosstalk mechanisms between  post-translational protein modification by ubiquitin and SUMO (Small Ubiquitin-like Modifier) in cooperation with the group of Prof. Dr. Huib Ovaa in our department. You will study the important roles of SUMO and ubiquitin in protein degradation at a proteome-wide level and at the level of individual target proteins.

You have obtained a PhD degree in biomedical sciences or a similar field and have a strong background in protein purification, protein biochemistry, molecular biology and cell biology. Experience with ubiquitin-like proteins and protein degradation will be a distinct advantage, whereas experience in mass spectrometry is not required. You should be highly motivated, enthusiastic and creative as well as skilled and results-driven. Excellent written and oral communication skills are a must.

You will be employed on the basis of 36 hours per week. Appointment is for three years. Your salary is based on your education and experience and is a maximum of  € 4,481  gross per month for a full time position (scale 10 in the Collective Labour Agreement for University Hospitals).

LUMC

You will be employed on the basis of 36 hours per week. Appointment is for a maximum of four years, to be completed with a doctoral thesis. Your salary will start with € 2,422 gross per month in the first year, amounting to a maximum of  € 3,103  gross per month in the fourth year based on a fulltime position (scale for PhD students in the Collective Labour Agreement for University Hospitals).

Cell and Chemical Biology

Within the Department of Cell and Chemical Biology, a team of professionals investigates functional regulation of proteins by post-translational modifications including SUMOylation, ubiquitylation and phosphorylation. This enables us to improve our knowledge about fundamental processes of life at the molecular level and to improve our knowledge about disease-linked de-regulation of these processes.