The group of Dr. Jacques Bothma currently has a vacancy for a technician to work on Quantitative imaging of transcription regulation in development.

Description of the project:
How an embryo interprets the noncoding parts of its genome to produce the different cell types necessary to build an animal is one of nature’s enduring mysteries. Unravelling it promises to not only yield new insights into disorders of development and cancer, but also reveal the organizing principles of life. Our lab approaches this problem by imaging the key regulatory proteins and regions of DNA mediating these decisions in their endogenous context in real time to understand the basic molecular mechanisms at work. We are constantly developing new ground-breaking imaging and labelling technologies that empower us to visualize and quantify these processes in ways that have never been done before. Our experimental workhorse is the early fruit fly (Drosophila melanogaster) embryo, but we are excited to expand into artificial vertebrate embryos and organoids in the future. The day to day work will require doing molecular cloning to create transgenes, husbandry of flies and quantitative microscopy of fly embryos.

We are looking for a candidate who is organised, curious by nature and excited to do science as part of a growing international and interdisciplinary team. Having previous experience with molecular biology, fly husbandry, microscopy or programming would be desirable but is not necessary as extensive training will be provided. The group’s work is highly interdisciplinary, so candidates with a background in either Biology, Physics, Chemistry or other related fields are strongly encouraged to apply.

Duration:
Initially one year with a potential extension.

Salary:
According to “CAO-Nederlandse Universiteiten” (CAO-NU), depending on experience scale 7, excluding 8% holiday allowance and an 8.3% year-end bonus. We offer an extensive package of fringe benefits.

Starting date:
As soon as possible.

Hubrecht Institute

The Hubrecht Institute is a research institute focusing on developmental and stem cell biology. It encompasses 24 research groups that perform fundamental and multidisciplinary research, both in healthy systems and disease models. The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW)., located on the Utrecht Science Park ‘De Uithof’. Since 2008, the institute has been affiliated with the University Medical Center Utrecht, advancing the translation of research into clinical practice. The Hubrecht Institute has a partnership with the European Molecular Biology Laboratory (EMBL).