Mechanism of chromatin replication

Description of the project: Cells replicate their genome and its organization into chromatin before cell division. These processes are essential for life, and when faulty, they may lead to cancer. The molecular mechanisms for faithful genome and chromatin replication remain largely unclear. Our lab developed new biochemical methods to study these processes at the molecular level. We combine these tools with cellular and structural analyses to elucidate how cells duplicate their epigenome.

The postdoctoral fellow will focus on the structural and biochemical characterization of key machineries involved in chromatin assembly during DNA replication. We collaborate with Prof. F. Foerster and Dr. R. Scheltema at Utrecht University to obtain high-resolution structural information of these molecules and we leverage our biochemical expertise to understand its functional implications.

Requirements: We are looking for a highly motivated and independent scientist, who thrives in a collaborative environment. The candidate should have a strong background in protein biochemistry and/or structural biology and related disciplines. Experience with cryo-EM is an advantage.

Fixed-term contract: 1 year with the possibility of an extension.

Terms of employment
Depending on education and experience for a full-time appointment scale 10 cao Nederlandse Universiteiten/KNAW. This is exclusive of 8% vacation allowance, 8.3% year-end bonus, travel allowance, internet allowance, home working allowance and pension accrual with ABP. The KNAW offers its staff an excellent package of secondary benefits. A package that meets the different needs of employees depending on their stage of life, lifestyle or career ambitions. For example, by working an extra two hours a week, it is possible to increase the number of days off from 29 to 41 days a year (with full-time employment). For a complete overview of the terms of employment, please refer to the web page: werken bij de KNAW.

Diversity & Inclusion
The KNAW considers a working environment in which everyone feels welcome and appreciated of great importance. A working environment in which attention is paid to individual quality and where development opportunities are paramount. Together we strive for an inclusive culture in which we embrace differences. We would therefore like to invite candidates who want to contribute to this through their background and experience. In the event of equal suitability, preference will be given to the candidate who thus enhances diversity within the Academy.

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Hubrecht Institute

The Hubrecht Institute is a research institute focusing on developmental and stem cell biology. At the institute, more than 20 research groups perform fundamental and multidisciplinary research, both in healthy systems and disease models. The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW) and is located on the Utrecht Science Park 'De Uithof'. Since 2008, the institute has been affiliated with the University Medical Center Utrecht, advancing the translation of research into clinical practice. The Hubrecht Institute has a partnership with the European Molecular Biology Laboratory (EMBL).

The Mattiroli lab is located at the Hubrecht Institute, a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), situated on the Utrecht Science Park. The institute is pioneering in developmental and stem cell biology, encompassing 22 research groups that perform fundamental, multidisciplinary research on healthy and diseased cells, tissues, and organisms.