In 2016 Professor Delwel's team has been awarded with the “Koningin Wilhelmina Cancer Research” price. With this price, four positions have become available dedicated to study molecular mechanisms of transformation in acute myeloid leukemia.

You will be working in a team of Molecular and Cellular Biologists. The focus of our research team is to understand the mechanisms of enhancer mediated deregulation of gene expression in patients with acute myeloid leukemia. To study the effects of enhancer mutations in leukemia development in vitro and in vivo, functional genomics and CRISPR/Cas9 genome editing, combined with next generation sequencing will be applied. Cas9-mediated enhancer mutagenesis- and CRISPRi/shRNA screens will be applied to uncover the protein/enhancer complexes involved in aberrant gene activation.

The ultimate goal of the study will be to interfere with aberrant gene control and leukemia cell growth. The Postdoctoral fellow, PhD student and Research Technician will be fully employed in “Wet-Lab” experiments. Large genome and epi-genome data sets will be derived in cohorts of human leukemia samples. The Bio-Informatician will be responsible for the processing and analyses of these data sets.

Please check www.erasmusmc.nl/werkenbij/vacatures/ for the individual qualifications for every position :

1. Post Doctoral Fellow (vacancy code 21.17.17.TDdH)
2. PhD-Student (vacancy code 17.06.17.TDdH)
3. Research Technician (vacancy code 17.02.17.TDdH)
4. Bio-Informatician (vacancy code 21.18.17.TDdH)

Please check www.erasmusmc.nl/werkenbij/vacatures/ for the individual terms of employment for every position :

1. Post Doctoral Fellow (vacancy code 21.17.17.TDdH)
2. PhD-Student (vacancy code 17.06.17.TDdH)
3. Research Technician (vacancy code 17.02.17.TDdH)
4. Bio-Informatician (vacancy code 21.18.17.TDdH)

Erasmus MC

A healthy population and excellence in healthcare through research and education. This is what Erasmus MC stands for. Conducting groundbreaking work, pushing boundaries and leading the way. In research, education, and healthcare. We are practical people with a high level of expertise, working hard to improve and renew the healthcare of today and the public health of tomorrow.

Hematology

The Department of Hematology at the Erasmus MC Cancer Center has a major focus on the improvement of diagnosis and treatment of hematological malignancies. The department contains a Transplantation Unit, a Hemostasis laboratory and a Hemato-Oncological Laboratory, where you will be situated.

You will work in a research group (Professor Ruud Delwel) which is embedded in a larger team of investigators, including Group leaders, Post doctoral Fellows, PhD candidates, Medical Docters, Bio-Informaticians and Technicians, who together form the Hemato-Oncology laboratory at Erasmus MC. The project in which you will participate, aims at understanding the mechanisms of aberrant gene expression in leukemia caused by defects in regulatory elements in the genome of leukemia cells. The work is also part of the research that was recently awarded with the Koningin Wilhelmina Research Price 2015.