Optical coherence tomography (OCT) is a powerful imaging technique that shows internal structure of tissues with micrometer-order resolution. OCT has been used in various clinical applications, such as pathology, cardiology, ophthalmology and dermatology. Applied in treatment of coronary artery disease, intravascular OCT (IV-OCT) is capable of imaging the structural features of atherosclerotic plaques. The reliance on structural image features for tissue classification, however, may lead to confusion in image interpretation. To achieve a more accurate diagnosis, we have proposed a novel imaging modality, called thermo-elastic OCT (TE-OCT). TE-OCT is a multimodal imaging technique that is based on conventional OCT, but relies on optical absorption in addtion to scattering. The TE-OCT images are constructed by detecting the tiny thermo-elastic deformation that is related to the optical and mechanical properties of the tissue. Thereby, TE-OCT images that contain the tissue type information can be provided together with the structral OCT images to the physician.

The PhD candidate will explore the TE-OCT concept by studying the technical principle, developing prototype scanning devices and carrying the prototypes to biomedical applications. Along this proof-of-concept research line, the PhD candidate will gain experience on optical design, system development, laser-tissue-interaction and pre-clinical/clinical studies. The candidate will also have opportunities to participate in clinical, industrial and international research collaborations.

We are looking for candidates with an MSc degree in Physics, Electrical Engineering or a closely related discipline. Experience in optics, lasers or biophysics is a plus. The research project should result in a PhD thesis.

Being able to present a certificate of good conduct is a condition for the appointment.

The gross monthly salary is € 2.222,- in the 1st year and increases to € 2.846,- in the 4th year (scale OIO). The terms of employment are in accordance with the Collective Bargaining Agreement for University Medical Centers (CAO UMC). In case of an PhD appointment: You will receive a temporary position for 4 years.

Erasmus MC

A healthy population and excellence in healthcare through research and education. This is what Erasmus MC stands for. Conducting groundbreaking work, pushing boundaries and leading the way. In research, education, and healthcare. We are practical people with a high level of expertise, working hard to improve and renew the healthcare of today and the public health of tomorrow.

Thoraxcenter Biomedical Engineering is part of Thoraxcenter, Erasmus MC. The research groupd is led by Prof. dr. ir. A. F. W. van der Steen. At the crossroads of physics, technology, biology and medicine we are developing inovative techniques and methods to enhance insights to improve diagnosis and treatment of cardiovascular diseases.