Within this project the PhD student will be examining the (epi)genetic program of pluripotent stem cells as they arise in the embryo. Pluripotency, the ability to generate all the embryonic lineages, arises during pre- and peri-implantation embryonic development as the result of a sequence of distinct genome remodeling events, much of which remains to be elucidated. Chromatin and epigenome analyses, embryo manipulations, advanced microscopic imaging, genetic manipulations, (re)programming and stem cell functional analyses will be applied to study the epigenetic mechanisms that control the development of pluripotency and the transition between different pluripotent states, in human and mouse embryos and pluripotent stem cells. Not only will this research advance the use of reprogramming techniques and pluripotent stem cells in human medicine, some of the reprogramming mechanisms employed during the development of pluripotency contribute to oncogenesis and may inspire novel avenues towards treatment.

We are looking for a talented candidate with a MSc Degree, preferably with a background in cell or Developmental Biology or Biochemistry. The applicant should possess or be willing to obtain article 9 authorization for animal handling. Above all we look for a candidate who is ambitious and pairs independent thinking with a collaborative nature and is eager to pursue a scientific career in the field of stem cell biology.

Being able to present a certificate of good conduct is a condition for the appointment.

You will receive a temporary position for 4 years. The gross monthly salary is €2.279 ,- in the 1st year and increases to € 2.919,- in the 4th year (scale OIO). The terms of employment are according to the Collective Bargaining Agreement for Dutch University Medical Centers (CAO UMC).

Erasmus MC

A healthy population and excellence in healthcare through research and education. This is what Erasmus MC stands for. Conducting groundbreaking work, pushing boundaries and leading the way. In research, education, and healthcare. We are practical people with a high level of expertise, working hard to improve and renew the healthcare of today and the public health of tomorrow.

The Department of Cell Biology houses innovative technologies and top level facilities to support its research programs, and is embedded in the dynamic, internationally competitive research community of over 40 biomedical research labs within Erasmus MC. The main language of the research community is English.