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Job The Netherlands Cancer Institute (NKI-AVL) - Postdoc Molecular Genetics

The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL) is looking for a fulltime Postdoc Molecular Genetics - 36-hours

Specifications - (explanation)

Location Amsterdam, The Netherlands
Function typesTechnical, Laboratory positions, Postdoc positions, Research, Development, Innovation
Scientific fieldsNatural Sciences
Hours 36.0 hours per week
Salary € 2443 - € 4095
EducationDoctorate
Job number AT 237
Translations
About employer The Netherlands Cancer Institute
Short link www.academictransfer.com/16288

Job description

Title of the project:

Functional Characterization of Novel Candidate Oncogenes Implicated in Breast Cancer.

Project information:

The purpose of the project is to functionally characterize candidate oncogenes previously discovered using retroviral insertional mutagenesis in mice.

Background: We have identified a large number of novel candidate oncogenes in MMTV induced mammary tumors that developed in wild-type and various genetically modified mice. A number of these genes have been validated as genuine cancer genes and the oncogenic pathways in which several of these genes act have been established. Three of these genes belong to the R-spondin gene family and in transgenic mice, conditionally expressing one of these genes, various tissues are affected leading to dysplasia’s, hyperplasias and tumor formation. The purpose of this project is to functionally investigate these and possible other genes from the insertional mutagenesis screens using various genetic, biochemical and cell biological techniques. Also the clinical relevance of the novel genes will be studied.

The Netherlands Cancer Institute has a strong background in basic research, excellent core facilities and offers a highly international and interactive work environment.

Requirements

We are looking for highly motivated and enthusiastic researcher with a PhD in biology or biomedical sciences with a strong background in molecular biology, training in cell biology and affinity for genetics and bioinformatics. Fluency in spoken and written English is a requirement. The postdoc should have an interest in research focused on both fundamental and clinically relevant aspects of tumorigenesis. Experience with mouse models will be appreciated.  

Conditions of employment

The temporary employment will be for a period of 3 years. The gross salary per month will be from € 2.443,- to € 4.095,- according to the FWG-function group
55-60, depending on education and previous experience. The terms of employment will be in accordance with the CAO Ziekenhuizen (Collective Labour Agreement for Hospitals).

Contract type: Temporary, 3 years

Organisation

The Netherlands Cancer Institute (NKI-AVL)

The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital (NKI-AVL) covers all major areas of cancer research and has special interest in adoptive cell therapies, requiring close collaboration between clinical and basic scientists.

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The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL) is looking for a fulltime Postdoc Molecular Genetics - 36-hours

Specifications - (explanation)

Location Amsterdam, The Netherlands
Function typesTechnical, Laboratory positions, Postdoc positions, Research, Development, Innovation
Scientific fieldsNatural Sciences
Hours 36.0 hours per week
Salary € 2443 - € 4095
EducationDoctorate
Job number AT 237
Translations
About employer The Netherlands Cancer Institute
Short link www.academictransfer.com/16288

Job description

Title of the project:

Functional Characterization of Novel Candidate Oncogenes Implicated in Breast Cancer.

Project information:

The purpose of the project is to functionally characterize candidate oncogenes previously discovered using retroviral insertional mutagenesis in mice.

Background: We have identified a large number of novel candidate oncogenes in MMTV induced mammary tumors that developed in wild-type and various genetically modified mice. A number of these genes have been validated as genuine cancer genes and the oncogenic pathways in which several of these genes act have been established. Three of these genes belong to the R-spondin gene family and in transgenic mice, conditionally expressing one of these genes, various tissues are affected leading to dysplasia’s, hyperplasias and tumor formation. The purpose of this project is to functionally investigate these and possible other genes from the insertional mutagenesis screens using various genetic, biochemical and cell biological techniques. Also the clinical relevance of the novel genes will be studied.

The Netherlands Cancer Institute has a strong background in basic research, excellent core facilities and offers a highly international and interactive work environment.

Requirements

We are looking for highly motivated and enthusiastic researcher with a PhD in biology or biomedical sciences with a strong background in molecular biology, training in cell biology and affinity for genetics and bioinformatics. Fluency in spoken and written English is a requirement. The postdoc should have an interest in research focused on both fundamental and clinically relevant aspects of tumorigenesis. Experience with mouse models will be appreciated.  

Conditions of employment

The temporary employment will be for a period of 3 years. The gross salary per month will be from € 2.443,- to € 4.095,- according to the FWG-function group
55-60, depending on education and previous experience. The terms of employment will be in accordance with the CAO Ziekenhuizen (Collective Labour Agreement for Hospitals).

Contract type: Temporary, 3 years

Organisation

The Netherlands Cancer Institute (NKI-AVL)

The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital (NKI-AVL) covers all major areas of cancer research and has special interest in adoptive cell therapies, requiring close collaboration between clinical and basic scientists.