In this project you will take on the exciting challenge of understanding the functioning of eukaryotic replisomes at the single-molecule level. We are looking to hire a candidate who will study the dynamics of helicase loading, helicase maturation, and replication elongation, among other topics. To do this, you will utilise our high-throughput, physics-based, single-molecule force spectroscopy and fluorescence imaging systems that are capable of acquiring large datasets under a variety of different conditions. You will be involved in the purification and labelling of proteins as necessary. You will analyse resulting datasets using biophysical modelling, and discuss extensively with collaborators in the areas of molecular biology and biochemistry.

We are looking to hire outstanding experimentalists for this exciting collaborative project. We are in particular looking for a prospective post-doctoral researcher who is keen to head a biophysical project designed to understand the mechanistic aspects of novel protein function. As a post-doctoral researcher on this project, you will be responsible for planning and carrying out the experiments and for analysing the data. You will be expected to contribute to the interpretation of the biophysical experiments on the basis of detailed analysis, to acquire an in-depth knowledge of the background literature, and to integrate the results of your data with those of ongoing molecular biology and biochemistry experiments in the field. A strong background in physics or biophysics is a an absolute must, as is a good command of spoken and written English.

Fixed-term contract: 3 years.

The TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers child care and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.

For more information about this position, please contact Lab Manager Dr. Belen Solano Hermosilla, phone: +31 (0)15-2783219, e-mail: b.p.solano-hermosilla-1@tudelft.nl. Applications should include a letter of application, a detailed CV, and the names and contact information of three references. The deadline for applications is 15 November 2017. Applications may be sent electronically to both Dr. Belen Solano Hermosilla b.p.solano-hermosilla-1@tudelft.nl and Dijana Boric D.Boric@tudelft.nl.
When applying for this position, please refer to vacancy number TNWBN16-019.

Delft University of Technology

Delft University of Technology (the TU Delft) is a multifaceted institution offering education and carrying out research in the technical sciences at an internationally recognised level. Education, research and design are strongly oriented towards applicability. The TU Delft develops technologies for future generations, focusing on sustainability, safety and economic vitality. At the TU Delft you will work in an environment where technical sciences and society converge. The TU Delft comprises eight faculties, unique laboratories, research institutes and schools.

http://www.tudelft.nl

Applied Sciences

The recently-established, vibrant Department of Bionanoscience focuses on research at the interface between nanoscience, synthetic biology, and cell biology. It studies single cells in all their complexity down to the molecular level, from both fundamental scientific and application points of view. The department operates as part of the Kavli Institute of Nanoscience at the Faculty of Applied Sciences and occupies a leading international position.

The Nynke Dekker lab encompasses approximately twenty scientists working on different aspects of genome processing and molecular machines. You will be part of this group and will interact actively with current members.