Voltage imaging is the optical detection of cellular electrical signalling. It promises new neuroscientific insights through the imaging of circuit dynamics deep in the living brain at previously inaccessible scales of time and space, detailed biophysical understanding of cellular signaling through detection of membrane voltage dynamics in subcellular compartments, and new avenues of disease modelling and therapeutic research through massively parallel recording of neural dynamics.
You’ll work on a multidisciplinary project at the cutting edge of this developing field.
Potential projects include:
• Nanoscopic investigations of signalling dynamics in synapses
• Investigation of developing zebrafish brains through absolute voltage imaging
• Development of multiphoton voltage imaging techniques for mouse brains.

You have a background in neuroscience, optogenetics, molecular biology, chemistry, physics or nanotechnology, and an interest in multidisciplinary science. Examples of desirable experience include: experimental microscopy, nanophotonics or electrophysiology; design/construction of imaging setups; data analysis/modelling; tissue slice/in vivo experiments (zebrafish/mouse); behavioral training; protein engineering; cloning; tissue culturing or DAQ programming.
You communicate well in English, are happy to learn skills out of your comfort zone and actively engage collaborators outside the lab.

Fixed-term contract: 2 years.

The TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers child care and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.

For more information about this position, please contact Dr. D. Brinks, phone: +31 (0)15-2788161, e-mail: d.brinks@tudelft.nl. To apply, please e-mail a detailed CV with a letter of application, a research statement summarising previous work experience and research interests, and contact information of references by to Ms. J.T. van Vliet, j.t.vanvliet@tudelft.nl. This vacancy will remain open until suitable candidates have been found.
When applying for this position, please refer to vacancy number TNWIP17-045.

Delft University of Technology

Delft University of Technology (the TU Delft) is a multifaceted institution offering education and carrying out research in the technical sciences at an internationally recognised level. Education, research and design are strongly oriented towards applicability. The TU Delft develops technologies for future generations, focusing on sustainability, safety and economic vitality. At the TU Delft you will work in an environment where technical sciences and society converge. The TU Delft comprises eight faculties, unique laboratories, research institutes and schools.

http://www.tudelft.nl

Applied Sciences

The Faculty of Applied Sciences has a strong programme in Imaging Physics in which new instrumentation and new methods are developed for microscopy and medical imaging. The Imaging Physics programme has led to innovations in electron microscopy, lithography, light microscopy, ultrasound imaging, terahertz imaging, focused ion beam milling, plus many quantitative image processing methods. Most of the instruments in the lab are prototypes with unique functionalities. Instrumentation is developed in collaboration with scientific and industrial users for evaluation and first scientific observations.

Post-doc positions are available in the new Neuroimaging lab (www.brinkslab.org) at Delft University of Technology. We are building a multidisciplinary team to work on voltage imaging, at the interface of optical physics, molecular biology, and neuroscience. This includes design of innovative optical imaging schemes, creation of new and improved voltage sensors, biophysical interpretation of voltage imaging data, and application in neuroscientific studies.
We value a collaborative environment, both within the lab and between labs. Joint appointments with Erasmus MC Rotterdam are a possibility.