We are searching for a scientist who is interested to push the frontiers of biosensing with a bottom-up biophysical approach. The candidate should have experience with (a) the design of molecules and molecular structures and (b) studies of their functional properties with single-molecule resolution. The aim is to develop novel concepts for recognition and transduction for real-time monitoring of molecules and molecular processes in complex macromolecular environments.

About Eindhoven University of Technology (TU/e):
The TU/e is a University of Technology with a focus on Health, Energy and Mobility. Within the Health area, several departments cooperate on topics such as Chemical Biology, Regenerative Medicine, Computational Biology, and Biosensing, with close links to healthcare and industry. The TU/e is an open and inclusive university with short communication lines. The people are curious, collaborative, and strive for excellence. TU/e enables its academic staff to develop research and education at an internationally renowned level. Our lively campus community facilitates connections between staff and students, in an open, friendly, vibrant atmosphere that welcomes and inspires.

About the Department of Biomedical Engineering (BME):
The Department of Biomedical Engineering offers a research driven BME Bachelor program and Masters Biomedical Engineering, Medical Sciences and Technology and Medical Engineering in its Graduate Program. Research areas range from Molecular Bioengineering and Imaging, Biomechanics and Tissue Engineering to Biomedical Imaging and Modeling. The department has more than 800 students and up to 200 tenured and non-tenured employees.

About the Institute for Complex Molecular Systems (ICMS):
The Institute for Complex Molecular Systems is an interdisciplinary institute at Eindhoven University of Technology (TU/e) which brings excellent researchers from different areas together to promote cross-breeding of ideas across disciplines in the departments Biomedical Engineering, Applied Physics, Chemical Engineering and Chemistry, Mathematics and Computer Science, and Mechanical Engineering. The institute aims to create and study biologically relevant functional structures with the ultimate goal of understanding the complexity of life.

About Biosensing:
The group Molecular Biosensing for Medical Diagnostics (MBx, see www.tue.nl/mbx) aims at creating ideas and generating scientific insights in the area of molecular biosensing technologies. This involves the engineering of molecular constructs for sensing applications (using protein, nucleic-acid, and protein-DNA technologies), methods to biofunctionalize nanoparticles, methods to characterize particle behavior in complex environments (e.g. protein corona), the development of novel single-molecule measurement methods, optical microscopies, particle characterization techniques, plasmonic effects, particle actuation principles, signal processing, and simulations. The group develops technologies to detect proteins and study protein function with single-molecule sensitivity in complex macromolecular environments. The research leads to novel methods for molecular biosensing, insights into protein function within complex and crowded environments, and novel routes into point-of-care and patient monitoring applications. Laboratories are shared with the Chemical Biology research group of the Department of Biomedical Engineering (www.tue.nl/cb) and the Institute for Complex Molecular Systems (www.tue.nl/icms).

You have a PhD and several years of research experience in the fields of biophysics (including single-molecule methods) and molecular engineering (for example biochemistry, molecular biology, analytical chemistry, DNA nanotechnology, protein engineering).

You have proven abilities in designing and realizing functional molecular structures and in developing quantitative mechanistic understanding of molecular function.

Other important assets are: scientific and education qualities, personal initiative and originality, collaboration capacity, experience in coaching and guiding students, PhD students and junior faculty members, potential to enhance and complement the research ecosystem, and the ability to successfully team up with peers to attract research funding.

We offer you:

A challenging job in a dynamic and ambitious university.

A position as assistant professor or associate professor. The type of position as well as tenure depend on the profile of the candidate.

Part-time employment (min 80%) is possible.

The gross monthly salary is in accordance with the Collective Labor Agreement of the Dutch Universities (CAO NU), depending on your experience.

An attractive package of fringe benefits, including excellent work facilities, child care, moving expenses, sports facilities, an extra holiday allowance (8% in May), and an end-of-year bonus (8.3% in December).