The group Molecular Biosensing for Medical Diagnostics (MBx, see www.tue.nl/mbx) at Eindhoven University of Technology (TU/e) creates ideas and generates scientific insights in the area of molecular biosensing with single-molecule resolution. This involves the engineering of molecular constructs for sensing applications (using protein, nucleic-acid, and protein-DNA technologies), methods to biofunctionalize nanoparticles, the development of novel single-molecule measurement methods, optical microscopies, particle characterization techniques, plasmonic effects, particle actuation principles, signal processing, and simulations. The research leads to novel methods for molecular biosensing, insights into protein function within complex and crowded environments, and novel routes into point-of-care and patient monitoring applications. The MBx group initiated and organizes the international competition on Sensors for Health (www.sensus.org). Laboratories are shared with the Chemical Biology research group (www.tue.nl/cb) and the Institute for Complex Molecular Systems (www.tue.nl/icms).

PhD project

The PhD position is part of a collaboration between TU/e, Wageningen University and Research Centre (WUR), and six companies: Philips, Future Diagnostics, HyTest, Scienion, Stratec, and Synaffix. The PhD project at TU/e focuses on the development, characterization and understanding of surfaces for biosensing with single-molecule resolution. We propose a 'Molecular Gecko' approach, wherein antibodies with precisely defined linker polypeptides (provided by WUR) are attached to otherwise anti-fouling polymer-coated sensor surfaces. This new technology will be investigated and later demonstrated in experiments with medically-relevant biomarkers.

We are looking for enthusiastic candidates who are in an MSc program or who already have an MSc degree, preferably in Chemistry, Physics, Biomedical Engineering, or Nanotechnology. An interest in Physical Chemistry or Biophysics is required. Experience in advanced microscopies or single-molecule methods is a plus.

We offer:

A challenging job at a dynamic and ambitious University and in an enthusiastic team.

An appointment (1 fte) as a PhD-student for four years, starting date: as soon as possible.

Gross monthly salaries are in accordance with the Collective Labour Agreement of the Dutch Universities (CAO NU), increasing from
€ 2191 per month initially, to € 2801 in the fourth year.

An attractive package of fringe benefits, including excellent work facilities, end of the year allowance and sports facilities.