In a research project funded by the Dutch Cancer Foundation (KWF) you will study the functional relationship between MYC and the TSC-mTORC1-pathway in cancer biology. Understanding the oncogenic functions of the oncogene MYC are critical long-term goals in cancer research. Currently, the options to directly targeting MYC are limited and their applicability in therapy are uncertain. Resent results from our lab point to novel possibilities for treatment of MYC-driven cancers like Burkitt lymphoma or lung cancer by using a synthetic lethal approach through modulation of the TSC-mTORC1-mitochondrial metabolism regulatory axis. We aim to reveal the involved molecular mechanisms, mitochondrial biology as well as the therapeutic possibilities of this synthetic lethal interaction. To achieve our scientific goals our lab combines a wide variety of molecular biology techniques with experimental mouse models, and we collaborate with basic and clinical researchers.

Requirements Postdoc
- Proven track record in life science, medical biology or related area
- Inquisitive and independent research attitude
- Excellent communication skills and a team player
- Experience with mice is a big plus

Requirements PhD student
- Completed education in life science, medical biology or related area
- Inquisitive and learning research attitude
- Excellent communication skills and a team player

The UMCG has a preventive Hepatitis B policy. You may be required to build up sufficient protection against Hepatitis B before you can be appointed. Vaccination is provided by the UMCG if necessary.

The duration of the PhD project is four years. It concerns a fulltime appointment (36 h/week). After one year, the performance of the candidate will be evaluated to decide on continuation of the contract. Your salary is € 2.279,- gross per month in the first year up to a maximum of € 2.919,- gross per month in the last (fourth) year (scale PhD).

The Post-doc position is initially one year with the possibility for extension. Your salary will be a maximum of € 4.216,- gross per month (scale 10), depending on your qualifications and relevant experience, based on a full-time appointment.

For both positions:
In addition, the UMCG will offer you 8% holiday pay, an 8.3% end-of-year bonus and a development budget. The terms of employment comply with the Collective Labour Agreement for Medical Centers (CAO-UMC).

For more information visit the website of the Calkhoven lab or contact Cor Calkhoven, Team leader, ERIBA; email: c.f.calkhoven@umcg.nl (please do not use this e-mail address for applications)

Applications
Full applications including a motivation letter, your resume and two contacts for reference letters will receive full consideration if received before 14 January 2018.
Please use the the digital application form at the bottom of this page - only these will be processed. Immediately after sending the digital application form you will receive an email- confirmation with further information.

ERIBA: The European Research Institute for the Biology of Ageing

ERIBA, the European Research Institute for the Biology of Ageing, is a newly established institute at the University Medical Centre Groningen (UMCG). The mission of ERIBA is to better understand the molecular mechanisms that result in age-related decline and age-related diseases. We aim to develop novel strategies to prevent or combat age-related diseases and to provide evidence-based recommendations for healthy ageing. The research teams are working with different model systems and technology platforms and share their knowledge and expertise to accelerate discoveries. The ERIBA is housed in a new building and is part of the central UMCG campus in the vibrant University City Groningen in the north of the Netherlands.

The Calkhoven lab at ERIBA is looking for a post-doctoral researcher and PhD student.