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Job Radboud University Nijmegen Medical Centre (RUN MC) - Postdoc Interplay of DC-Script and type I- and II Nuclear Receptors

Specifications - (explanation)

Location Nijmegen
Function typesPostdoc positions
Scientific fieldsHealth
Hours 36.0 hours per week
EducationDoctorate
Translations
About employer Radboud University Medical Center (Radboudumc)
Short link www.academictransfer.com/12449

Job description

Breast cancer is a common cause of cancer-related death in women. The incidence, prognosis and treatment efficacy of breast cancer are known to be affected by the nuclear receptor (NR) repertoire that breast (cancer) epithelial cells express. We recently identified the NR modulating protein DC-SCRIPT/ZNF366 and showed that DC-SCRIPT modulates the activity of two classes of NRs, including ER and RAR. Importantly, DC-SCRIPT constitutes an independent prognostic marker for breast cancer. The overall aim is to determine the effect of DC-SCRIPT on the biological response of breast cancer cells in environments with different type I/II NR agonists and to investigate the underlying molecular mechanism(s).
 
Three interconnected questions are:.
1. What is the effect of DC-SCRIPT on the biological response of breast cancer cells in vitro to type I/II NR agonists applied individually or simultaneously?
2. What is the influence of the local tumour-microenvironment on the effect of DC-SCRIPT?
3. What is the molecular mechanism by which DC-SCRIPT modulates type I and type II NR regulated transcription?  

Requirements

Candidates should have obtained a PhD degree in Molecular Cell Biology / Immunology or equivalent. In particular experience with cell culture and interest in immunology / cell biology is of relevance. Techniques: Cell culture, Recombinant DNA technology, CHIP, Immunological techniques, flow cytometry. 

Conditions of employment

  • Temporary 1 - 3 years
  • 36 hours per week
  • Scale 10: max € 54906 gross per year at full employment

Organisation

Radboud University Nijmegen Medical Centre (RUN MC)

Nijmegen www.umcn.nl/ UMC St Radboud

Radboud University Nijmegen Medical Centre (RUN MC) is a leading academic centre for medical science, education and health care. Knowledge forms the heart of our organisation, connecting research, education and patient care. Over 10,000 staff and 3,500 students are committed and ambitious to contribute to the future of health care and medical science.

Driven by knowledge, empowered by people.

Department

The NCMLS and the Department of Tumor Immunology

NCMLS
The Nijmegen Centre for Molecular Life Sciences in the Netherlands is a leading European research school providing an outstanding research setting for the Radboud University Nijmegen. The NCMLS focuses on basic science and its translation into pioneering treatments for disease. NCMLS innovations are advanced through technology platforms such as genomics, proteomics, and molecular imaging.
 
Department of Tumor Immunology
Research within this department aims at a better understanding of our immune system using molecular-, cell biological- and immunological- techniques and is centred around dendritic cells (DCs) and regulatory T cells (Tregs) which play an important role in regulating the immune response.). In addition, the interplay between immune- and tumor cells is studied in the tumormicroenvironment. An important activity of the department is the translation of basic research into clinical application. 

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Specifications - (explanation)

Location Nijmegen
Function typesPostdoc positions
Scientific fieldsHealth
Hours 36.0 hours per week
EducationDoctorate
Translations
About employer Radboud University Medical Center (Radboudumc)
Short link www.academictransfer.com/12449

Job description

Breast cancer is a common cause of cancer-related death in women. The incidence, prognosis and treatment efficacy of breast cancer are known to be affected by the nuclear receptor (NR) repertoire that breast (cancer) epithelial cells express. We recently identified the NR modulating protein DC-SCRIPT/ZNF366 and showed that DC-SCRIPT modulates the activity of two classes of NRs, including ER and RAR. Importantly, DC-SCRIPT constitutes an independent prognostic marker for breast cancer. The overall aim is to determine the effect of DC-SCRIPT on the biological response of breast cancer cells in environments with different type I/II NR agonists and to investigate the underlying molecular mechanism(s).
 
Three interconnected questions are:.
1. What is the effect of DC-SCRIPT on the biological response of breast cancer cells in vitro to type I/II NR agonists applied individually or simultaneously?
2. What is the influence of the local tumour-microenvironment on the effect of DC-SCRIPT?
3. What is the molecular mechanism by which DC-SCRIPT modulates type I and type II NR regulated transcription?  

Requirements

Candidates should have obtained a PhD degree in Molecular Cell Biology / Immunology or equivalent. In particular experience with cell culture and interest in immunology / cell biology is of relevance. Techniques: Cell culture, Recombinant DNA technology, CHIP, Immunological techniques, flow cytometry. 

Conditions of employment

  • Temporary 1 - 3 years
  • 36 hours per week
  • Scale 10: max € 54906 gross per year at full employment

Organisation

Radboud University Nijmegen Medical Centre (RUN MC)

Nijmegen www.umcn.nl/ UMC St Radboud

Radboud University Nijmegen Medical Centre (RUN MC) is a leading academic centre for medical science, education and health care. Knowledge forms the heart of our organisation, connecting research, education and patient care. Over 10,000 staff and 3,500 students are committed and ambitious to contribute to the future of health care and medical science.

Driven by knowledge, empowered by people.

Department

The NCMLS and the Department of Tumor Immunology

NCMLS
The Nijmegen Centre for Molecular Life Sciences in the Netherlands is a leading European research school providing an outstanding research setting for the Radboud University Nijmegen. The NCMLS focuses on basic science and its translation into pioneering treatments for disease. NCMLS innovations are advanced through technology platforms such as genomics, proteomics, and molecular imaging.
 
Department of Tumor Immunology
Research within this department aims at a better understanding of our immune system using molecular-, cell biological- and immunological- techniques and is centred around dendritic cells (DCs) and regulatory T cells (Tregs) which play an important role in regulating the immune response.). In addition, the interplay between immune- and tumor cells is studied in the tumormicroenvironment. An important activity of the department is the translation of basic research into clinical application.