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Our research focuses on the elucidation of the molecular mechanisms underlying hormonal-mediated regulation of solute and water transport processes in epithelia including kidney and small intestine. The major emphasis is currently on the epithelial calcium (TRPV5 & TRPV6), magnesium (TRPM6 & TRPM7) and water (Aquaporin 2) channels, salt transporters (NCC, ENaC) and succinate receptors that constitute instrumental solute transport pathways in epithelia. The current projects aim to investigate in detail the regulation of these transport activities in health and disease. To this end, a wide variety of cutting edge techniques will be applied including cell and molecular biological, genetics biochemical and physiological procedures.
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