Our research focuses on the elucidation of the molecular mechanisms underlying hormonal-mediated regulation of solute and water transport processes in epithelia including kidney and small intestine. The major emphasis is currently on the epithelial calcium (TRPV5 & TRPV6), magnesium (TRPM6 & TRPM7) and water (Aquaporin 2) channels, salt transporters (NCC, ENaC) and succinate receptors that constitute instrumental solute transport pathways in epithelia. The current projects aim to investigate in detail the regulation of these transport activities in health and disease. To this end, a wide variety of cutting edge techniques will be applied including cell and molecular biological, genetics biochemical and physiological procedures. 

Tasks and responsibilities:

• The PhD student will design and perform scientific research in the area of molecular transport physiology in health and disease
• Generates and analyses the data in order to contribute to scientific publications and presents findings at scientific meetings
• Works in a team with other students and scientists to discuss, plans and performs research in a stimulating environment
• Works in a highly international research group with fellows from many countries
• Completes the project with a scientific dissertation

• MSc (medical) Biology or Chemistry
• Independent and well-structured working style
• Strong motivation to succeed in scientific researches
• Well-developed social skills directed to work in a team
• Experience with molecular biology
• Permitted to work with animals (art. 9) is a pre depending on the project

• Scale 10A: max € 38699 gross per year at full employment

Radboudumc (university medical center)

Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy film.

Our key strength is medical life-sciences and clinical practice, with an impressive infrastructure comprising state-of-the-art technology platforms and (translational) research facilities. The Radboudumc is therefore uniquely positioned in the emerging Euregio and Dutch healthcare infrastructure to play a leading role in the new healthcare paradigm of prediction, prevention and personalised medicine.

The Radboudumc focuses on scientific health challenges of today, with an eye on emerging diseases of the future.

Read more about what it means to work at Radboudumc and how you can do your part.

https://www.radboudumc.nl/EN/Pages/default.aspx

Physiology

The department of Physiology provides an international and stimulating working environment for its 50 employees and is an exciting place to perform basic research, translational and clinical medicine, and enjoy teaching. The department encompasses complementary research groups whose interests range from cardiovascular adaptations to inactivity, molecular regulation of ion transport processes in the kidney to the study of osmoregulation in the body. Working collaboratively within the department, we use our expertise to investigate how molecules, cells, organisms and humans function and how we might modulate their physiology to ultimately improve health in the patient.

The department consists of the research groups Integrative Physiology, Ion Transport and Osmoregulation and is part of the Nijmegen Centre for Molecular Life Sciences (NCMLS), a leading multidisciplinary graduate school within the domain of molecular mechanisms of disease and particularly in the fields of molecular medicine, cell biology and translational research. 

https://www.radboudumc.nl/en/research/departments/physiology