Sanquin has a post-doc position available where you will work on a blood cell generation project. This study is not only of scientific interest but will also provide a gold standard in different fields. Do you have a PhD degree and do you have interes in human (blood) cells?

We are looking for a post-doc for our blood cell generation project. Achieving the long-term goal of ex vivo blood cell generation for blood transfusion requires in-depth insight into the molecular mechanisms that drive specific blood cell differentiation. Most of this research is focused on dissecting transcriptional changes at the mRNA level. However, it has become increasingly clear that translation of RNA into protein is a highly regulated and cell-type specific process. To advance the field of personalized medicine, it is therefore of prime importance to study the differentiation of hematopoietic stem cells into functional blood cells at the protein level. In this project, we will generate proteomics-based protein expression profiles of cells of the entire hematopoietic landscape. This study is not only of scientific interest, but will provide a gold standard for

• quality assessment of novel cellular products,
• development of strategies to improve ex vivo blood cell formation,
• diagnosis of disease-causing blood cell defects and a better understanding of the function of blood cells under normal and pathophysiological conditions and,
• identification of cell specific proteins that can serve as potential biomarkers.  

• A PhD degree in chemistry, biology, (bio)molecular/biomedical/pharmaceutical sciences or equivalent;
• Expert proficiency in cell biology techniques, including isolation, characterization and cultivation of primary human (blood) cells;
• Experience in quantitative (prote)omics, data statistics, bioinformatics, and data reporting/visualization is an advantage;
• Problem-solving skills and capability to apply knowledge and experience to address complex challenges;
• A team player with good communication skills in English, who can work independently, but also as part of a multinational team.

Fixed-term contract: 3 years.

We offer a unique research opportunity in a dynamic environment. Nowhere else in the world can you find an organization that combines medical, pharmaceutical, diagnostic and scientific research under one roof.  In addition to a challenging project in a multi-disciplinary and enthusiastic team we offer:

• Salary and working conditions conform CAO Sanquin, based on 36 hours.;
• a full time contract of 36 hours per week for the duration of three years;
• 8,33% end-of-year bonus and 8,33% holiday pay;
• partial reimbursement of travel expenses;
• pension plan with Pensioenfonds Zorg & Welzijn (PFZW);
• collective discounts on various insurances;
• at fulltime employment (36 hours) 201 hours of leave per annum.

Sanquin is een not-for-profit organisatie, die de bloedvoorziening in Nederland verzorgt. Daarnaast produceert Sanquin geneesmiddelen uit plasma, maakt zij bloedgroep- en immuunreagentia, verricht zij wetenschappelijk en diagnostisch onderzoek en verzorgt zij onderwijs.

In this role you will work in the Laboratory of Proteomics at department of Molecular and Cellular Hemostasis. Our team is embedded in the Department of Molecular and Cellular Hemostasis, where a vibrant, international group of 35-40 colleagues (group leaders, postdocs, PhD students and technicians) are studying various aspects of hemostatic networks. We have academic affiliations with high-ranking universities in the Netherlands, including Utrecht University and the University of Amsterdam. The department’s research program benefits from the excellent research facilities, which include the latest technology for biomolecular mass spectrometry, imaging and cell sorting.