We invite applications for a PhD project in the field of behavioral neuroscience in rodents. This position is part of a translational research project investigating dysfunction of stress-hormone systems in PTSD with the aim to develop personalized treatment. The project is embedded in the Behavioral Neuroscience laboratory (PI: Benno Roozendaal) at Radboud university medical center and the Donders Institute for Brain, Cognition and Behaviour in Nijmegen (the Netherlands), in close collaboration with Dr. Erno Hermans (Radboudumc / Donders Institute), Prof. Dr. Robbert-Jan Verkes (Radboudumc / Donders Institute), and Dr. Gert-Jan Hendriks (ProPersona).

Post-traumatic stress disorder (PTSD) is a strongly debilitating psychiatric disorder characterized by a persistent remembering of the trauma by intrusive flashbacks, vivid memories or recurring dreams. There is a growing understanding that PTSD is a complex syndrome, with innumerable subtypes and variations. Since each subtype may call for a specific targeted therapy, there is a growing need to define subtypes of PTSD on the basis of biological markers. Notably, a large subgroup of PTSD patients exhibits dysregulations in the neuroendocrine stress system. This project proposes an integrated translational approach to investigate whether this dysregulation is directly associated with impairments in safety learning.

Within this translational and interdisciplinary project, the primary tasks of this PhD candidate will be to perform neurocircuitry-based behavioral studies in rodent models of extinction to investigate the association between stress-hormone (re)activity, functioning of fear-regulatory neural circuits, and quality of safety learning. The candidate will collaborate closely with cognitive neuroscience researchers who will employ state-of-the-art non-invasive methods (functional MRI, psychophysiology, psychopharmacology) to investigate these associations in PTSD patients. The ultimate goal of the project is to establish a proof of concept that stress-hormone dysregulation can serve as a biomarker for selection of mechanistically targeted treatments to improve safety learning.

The ideal candidate will have:

• A Master's degree in behavioral neuroscience or an adjacent field (biological, or biomedical);
• Experience in rodent research; behavioral testing and/or neural circuitry-based technologies (e.g., DREADD, optogenetics, or in vivo electrophysiology);
• The capacity to participate in an interdisciplinary, international, and translational research environment;
• A proactive and goal-directed attitude, good organizational skills, and the ability to finalize a PhD thesis within four years;
• Fluency in written and spoken English.
• *Candidates who only partially meet this profile are nonetheless strongly encouraged to apply.**

The intended start date for this position is September 2019, but can be flexible.

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center's HR Department will apply for this certificate on your behalf.

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Radboudumc

Research environment
The project is embedded in the unique and excellent infrastructure of the Donders Institute for Brain, Cognition and Behaviour. It is a highly dynamic institute with a collaborative atmosphere and particular interest into translational research. All facilities are fully research-dedicated laboratories with excellent technical support. The Donders Institute furthermore provides a unique and stimulating learning environment for young researchers, including a high-profile graduate school and in-house methodological expert courses.

Research into stress and stress-related disorders is an important focus area at Radboud university medical center. Researchers working on this theme jointly organize regular discussion meetings and lectures to promote integration of research conducted within molecular, cellular, systems, behavioral, and clinical neurosciences across campus.

Radboudumc
Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy.

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