In our group, we aim to understand the molecular and cellular requirements for optimal anti-tumor T cell responses. Your project concerns delineating key signaling pathways for optimal function in T cells and dendritic cells in vivo in mouse models, and matching mouse and human cellular systems in vitro. We collaborate with the ‘clinic’, and we aim to translate immunotherapy-assisted vaccination strategies to application in cancer patients. Techniques include: in vivo mouse work, flow cytometric and functional analyses of immune cells, genome-wide transcriptomic and epigenetic analyses and associated bioinformatics, and molecular biology including CRISPR/Cas9-mediated gene editing.

We are looking for an enthusiastic and ambitious PhD student, with a university master’s degree and a background in immunology and cell biology. You have affinity with mouse studies and a motivation to understand biological systems at the molecular level. ‘Article 9’ competence is advantageous. Fluency in spoken and written English is a requirement.  

Fixed-term contract: 4 years.

You will work 36 hours per week. You will be appointed for the duration of your studies, to be finished with a doctoral thesis, and for a maximum of four years. Your salary is a maximum of € 2,422 gross per month in the first year amounting to a maximum of € 3,103 gross per month in the final year, based on a fulltime position (scale Pro of the collective labor agreement of the University Medical Centers).

Leiden University Medical Center (LUMC)

At the Leiden University Medical Center, we continuously work on improving patient care. We invest in groundbreaking, international research and work with the latest equipment. Together with our team of doctors, medical specialists, teachers, academic researchers and supporting staff, we aim for the best quality in health care, education and international research. And we need you to realize our goals!

The Department of Immunohematology (IHB)

You will be working in the research group of Prof. Jannie Borst, who is the new head of the Department of Immunohematology (IHB). This research group has a high standing in the field of tumor immunology and connects within and beyond the department to exciting translational research lines on autoimmunity, infection, chronic inflammation and cancer, as well as to fundamental, innovative research lines in cell biology. The high end research infrastructure at the LUMC and Leiden University ensures that you can fully exploit your creativity.