Transforming growth factor-b (TGF-b) is of key importance in development and maintenance of tissue homeostasis. Work in the Ten Dijke lab is focused on the understanding how TGF-β signaling is perturbed in cancer, and to find new ways to target this pathway for therapeutic gain. In this role you focus on the development of synthetic bioactive molecules that selectively modulate protein-protein interactions or enzymatic activities involved in TGF-b signaling. Examples of such molecules include nanobodies, macrocyclic kinase inhibitors, PROTACs (Proteolysis targeting chimeric molecules) and modulators of the ubiquitin machinery. 

As a team we take a multidisciplinary approach, including high-throughput chemical screens, genetics, (bio)chemistry, cell biology, zebrafish/mouse models and mathematics and bioinformatics.

In short

·        You have a PhD degree in chemical or molecular cell biology

·        You will work on redirecting TGF-b signaling

·        You have multiple years of experience and expertise in the subject and as a researcher

You hold a PhD in chemical or molecular cell biology. You have expertise in biochemistry and multiple years of experience. You are highly motivated with proven research abilities and an excellent publication record. Furthermore, you are willing and able to work both independently and also collaboratively as part of a team.

Fixed-term contract: 2 years.

You will be employed on the basis of 36 hours per week. Appointment is for two years. Your salary is based on your education and experience and is a maximum of  € 4,481  gross per month for a full time position (scale 10 in the Collective Labour Agreement for University Hospitals).

LUMC

At the Leiden University Medical Center, we continuously work on improving patient care. We invest in groundbreaking, international research and work with the latest equipment. Together with our team of doctors, medical specialists, teachers, academic researchers and supporting staff, we aim for the best quality in health care, education and international research. And we need you to realize our goals!

Department Cell and Chemical Biology

The Department Cell and Chemical Biology is equipped with state-of-art facilities for molecular and cell biology, microscopy, chemistry, proteomics, genetics (including DNA editing) and protein chemistry. We believe that curiosity-driven experimental research by talented researchers is at the very heart of true progress in biomedicine.