Misregulation of TGF-b signalling has been implicated in many different diseases, including cancer, fibrosis and cardiovascular diseases. We have performed genetic gain and loss of function genetic and proteomic screens to identify novel druggable regulators of TGF-β pathways. In this project the mechanism of action and importance in disease of these novel regulators will be elucidated. In addition, we will harness the ubiquitin machinery (e.g. using PROTACs) to induce degradation of critical pro-oncogenic factors. You will contribute to this project.

Summary of the required skills

·        You hold a PhD degree and have a background in (bio)chemistry or molecular cell biology

·        You will work on a project focused on misregulation of TGF-b signalling

·        You will collaborate multidisciplinary

·        You will work with state-of-the-art equipment and in an innovative academic environment

We are searching for a highly motivated and experimentally talented scientist with drive to answer important fundamental research questions. You should hold a recent PhD and have a strong background in biochemistry and/or molecular cell biology. In addition, you have previous experience in signal transduction or chemical biology. Reporting and publishing the results in high impact scientific journals and at international conferences is expected.

Fixed-term contract: 2 years.

You will be employed on the basis of 36 hours per week. Appointment is for two years. Your salary is based on your education and experience and is a maximum of  € 4,481  gross per month for a full time position (scale 10 in the Collective Labour Agreement for University Hospitals).

LUMC

At the Leiden University Medical Center, we continuously work on improving patient care. We invest in groundbreaking, international research and work with the latest equipment. Together with our team of doctors, medical specialists, teachers, academic researchers and supporting staff, we aim for the best quality in health care, education and international research. And we need you to realize our goals!

Department of Cell and Chemical Biology

The Department of Cell and Chemical Biology is equipped with state-of-art facilities for molecular and cell biology, microscopy, chemistry, proteomics, genetics and protein chemistry. Furthermore, the LUMC is known for its innovative academic medical research with an multidisciplinary approach. We break new ground by working together.