Lipid metabolism is tightly regulated both at the cellular as well as whole-organism level. This regulation ensures that the level of lipids does not increase to toxic levels and that they are available at sufficient amounts for processes requiring them. Disruption of this balance is at the center of several pathological conditions in humans, most notably fatty liver and cardiovascular disease.

Our group is broadly interested in the transcriptional and post-transcriptional regulation of lipid and energy metabolism (e.g Zelcer et al., Science 2009; Zelcer et al. MCB 2014; Sharpe et al. TIBS 2014; Loregger et al. MCB 2015; Nelson et al. Circ Res 2016; Loregger et al. ATVB 2017; van Loon et al. ATVB 2018). To study lipid metabolism in the context of cardiovascular and metabolic diseases we use state-of-the art experimental in vitro and in vivo approaches including RNAseq, metabolomics, lipidomics, mass spectrometry, functional genetic screens, and disease models in mice. As a member of the group you will be directly involved in the ongoing research and will conduct independent experiments. Additionally, you will be responsible for the daily management of the research lab (e.g. ordering).  

We are looking for a highly-motivated and enthusiastic technician who is responsible, organized and able to work independently. Experience and affinity with lab management, molecular biology, and/or cell-based assays is an advantage. Excellent communicative skills and the ability to work within an international scientific research group are essential. The appointment will be initially for 1 year with a possibility for a subsequent permanent position. 

We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at Amsterdam UMC, AMC location means working in an inspiring and professional environment where development is encouraged in every respect.

• The maximum gross monthly salary based on a 36-hour work week is € 3.604,- (scale 8 CAO UMC)
• The base salary does not include allowances for irregular shifts, holiday pay (8%) and a year-end bonus (8.3%).
• We initially offer an appointment for a period of 1 year, with a possibility for a subsequent permanent position afterwards. 
• In addition to excellent accessibility by public transport, AMC location also has a sufficient number of parking spaces for employees.
• Pension is accrued at the ABP. AMC contributes a large part of the premium (70%).
• We have a very active staff association and organise various (sports) activities and events throughout the year.

For an overview of all our other terms of employment, see https://werkenbijamc.nl/arbeidsvoorwaarden/.

Amsterdam Universitair Medisch Centrum (Vumc)

The Zelcer group is located in the Department of Medical Biochemistry. Additional information on our research and group can be found on our website: http://www.zelcerlab.eu/.