Researcher (Postdoc) Unravelling the agonistic potential of MuSK Monoclonal Antibodies

Researcher (Postdoc) Unravelling the agonistic potential of MuSK Monoclonal Antibodies

Published Deadline Location
2 Dec today LEIDEN
Are you intrigued to study how patient-derived monoclonal antibodies function, and might have therapeutic potential? And would you like to be part of a young and dynamic team? Then read on.

Job description

You will be involved in ongoing research projects in the research group of Dr. Maartje Huijbers. The research group studies the pathophysiology of neuromuscular autoimmune diseases like myasthenia gravis (MG). In addition, there is a special interest in autoimmune diseases predominantly mediated by IgG4 autoantibodies. For one of these disorders, MuSK MG, monoclonal antibodies of patients have been isolated which facilitates the study of the pathophysiology of this disease. In addition, these antibodies have special features that might enable therapeutic applications. Your project will include the isolation of new monoclonal antibodies from patients’ immune cells and the analysis of the genetic, functional and immunological characteristics of these antibodies. You will identify the antibodies with the most favourable features in vitro and test their effects in in vivo models. The application of these antibodies in our animal models will be one of the most important aspects of this project. You will collaborate closely with a technician, who is also working on this project. These studies are facilitated by a variety of genomic and proteomic, antibody-oriented technologies, as well as a variety of cellular and animal models that the lab has at its disposal.

Specifications

Leiden University Medical Center (LUMC)

Requirements

You are an enthusiastic and driven researcher who enjoys working in a young and dynamic team with a focus on unravelling fundamental and mechanistic research questions. You have hands-on experience with common molecular biology tools (molecular cloning, mammalian cell culture, Western blotting, fluorescent microscopy, qPCR, etc) and animal experiments. Experience with FACS and RNA sequencing analysis is an advantage. You are accurate and able to work independently within a team. You have a flexible attitude, great sense of teamwork and possess excellent communication skills in English.

Conditions of employment

You will be employed on the basis of 36 hours per week. Appointment is for a minimum of 1 year, possibly to be extend for another 1.5 years. Your salary is based on your education and experience and is a maximum of  € 4,481  gross per month for a full time position (scale 10 in the Collective Labour Agreement for University Hospitals).

Employer

LUMC

At the Leiden University Medical Center, we continuously work on improving patient care. We invest in groundbreaking, international research and work with the latest equipment. Together with our team of doctors, medical specialists, teachers, academic researchers and supporting staff, we aim for the best quality in health care, education and international research. And we need you to realize our goals!

Department

Human Genetics

You will work in between two departments at the LUMC: Human Genetics (Prof. Dr. Silvère van der Maarel, head of the department) and Neurology (Prof. Dr. Jan Verschuuren, head of the department). Both departments have a longstanding collaboration on research of Neurological Motor Disorders. This research is embedded in the LUMC Medical Research Profile 'Translational Neurosciences'. The collaboration facilitates translational research based on fundamental research, patient material and clinical expertise. It is also supported through interactions with other departments both within and outside the LUMC. The Neuroimmunology research team is led by Dr. Maartje Huijbers.

Additional information

Your career at the LUMC

The LUMC stimulates you in maintaining and developing your knowledge and skills. We offer internal courses andand continuous training as well as services in terms of  mobility, personal development and career advice.

The key research lines of this research group can be found here.

Contact

Dr. Maartje Huijbers, senior researcher, Department of Human Genetics/Neurology

Telephone +31(0)71 526 94 84

Email: m.g.m.huijbers@lumc.nl.

Specifications

  • Research, development, innovation; Postdoc
  • Health
  • max. 36 hours per week
  • max. €4481 per month
  • University graduate
  • D.19.MH.RD.03

Employer

Leiden University Medical Center (LUMC)

Learn more about this employer

Location

Albinusdreef 2, 2333 ZA, LEIDEN

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Application procedure

References will be requested as part of the procedure and you will be asked to give a presentation.

Appointment is for a minimum of 1 year, possibly to be extend for another 1.5 years.

Apply for this job

Apply for this job

This application process is managed by the employer (Leiden University Medical Center (LUMC)). Please contact the employer for questions regarding your application.

Apply for this job via the employer's website

Application procedure

Application procedure

References will be requested as part of the procedure and you will be asked to give a presentation.

Appointment is for a minimum of 1 year, possibly to be extend for another 1.5 years.

Make sure to apply no later than 15 Dec 2019 23:59 (Europe/Amsterdam).