The innate immune system is crucial to protect the body against pathogens. On the other hand, innate immune mechanisms are sometimes unintentionally activated by self-derived ligands. Such a sterile inflammatory response occurs in autoinflammatory and autoimmune disorders and it is a hallmark of the tumor microenvironment. How does the innate immune system discriminate between the body's own molecules and microbial ones to ensure an effective immune response against invaders, while avoiding self-directed inflammation? What are the molecular mechanisms that suppress unwanted activation of innate immunity? How can we harness sterile inflammation to boost the body's anti-tumor immune response? If you are interested in these fundamental questions, come and strengthen our team! We are using molecular, biochemical and cell-based approaches in our research. The advertised project focuses on nucleic acid sensing and the type I interferon response and has a strong molecular basis.

We are looking for an excellent and ambitious candidate with an MSc degree or PhD Biomedical Sciences or a related field, and with a proven track record of achievement. Experience in the field of molecular biology and/or (innate) immunity is an absolute must. Knowledge of the ubiquitin system and/or genetic screening is desirable. A suitable candidate is driven, able to work independently as well as in a multi-disciplinary team and has outstanding organizational skills. We expect a proactive and goal-oriented attitude and are looking for someone that can drive multiple aspects of a project. Excellent verbal and written communication skills in English are essential. Postdocs are strongly encouraged to apply for postdoctoral fellowships shortly before or after joining the group.

Fixed-term contract: min. 2 years.

As a PhD candidate, you will be appointed for the duration of four years. Your salary is a maximum of € 2,422 in the first year, amounting to a maximum of € 3,103 in the final year (scale PhD students, Collective Labour Agreement University Medical Centers).

As a postdoc, you will be appointed for a minimum of two years, with a possible extension of one or two years. Your salary is based on your experience and education and amounts to a maximum of € 4,481 gross per month on a fulltime basis (scale 10, Collective Labour Agreement University Medical Centers).

Department of Immunohematology & Blood transfusion (IHB)

The lab is embedded within the Department of Immunohematology & Blood transfusion (IHB) and closely collaborates with the Cell and Chemical Biology department at the LUMC. Both departments contribute to the improvement of healthcare with ground breaking research with state of the art equipment.