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Within the Laboratory of Proteomics at the department of Molecular and Cellular Hemostasis we are looking for a post-doc or PhD student to unravel the proteomic landscape of blood cell generation.
Circulating red blood cells, platelets and white (immune) blood cells are continuously replenished from hematopoietic stem cells residing in the bone marrow. Detailed insight into the molecular mechanisms that drive the differentiation of hematopoietic stem cells towards specialized blood cell types is required to enable the next step in the ex vivo generation of blood cells. Our current efforts to gain a better understanding on these self-renewal and differentiation processes are mainly focused on mapping transcriptional changes. However, it is becoming increasingly clear that translation of RNA into protein is a highly regulated and cell-type specific process and that transcriptomics poorly reflects the functional protein levels. Therefore, in this project you will generate a proteomics-based protein expression atlas of the hematopoietic landscape ranging from bone marrow-derived progenitor cells to highly specialized circulating blood cells. This study is multi-faceted: not only serving scientific interest, but also providing a gold standard for i) quality assessment of novel cellular products, ii) development of strategies to improve ex vivo blood cell formation and iii) diagnosis of disease-causing blood cell defects and a better understanding of the function of blood cells under normal and pathophysiological conditions.
Fixed-term contract: 3 years.
We offer unique research opportunities in a dynamic environment. Nowhere else in the world you will find an organization that combines medical, pharmaceutical, diagnostic and scientific research under one roof. In addition to a challenging project in a multi-disciplinary and enthusiastic team we offer:
The Laboratory of Proteomics is embedded in the department of Molecular and Cellular Hemostasis and is a frontrunner in applying state-of-the-art mass spectrometry-based proteomics within the scientific framework of Sanquin Research. We are a vibrant, international group of 35-40 colleagues (consisting of group leaders, postdocs, PhD students and technicians) that study the various aspects of hemostatic networks. Our department has academic affiliations with high-ranking universities in the Netherlands, such as Utrecht University and the University of Amsterdam. The department’s research program benefits from excellent research facilities, which include the latest technology for biomolecular mass spectrometry, imaging and cell sorting.
Sanquin Blood Supply Foundation (Sanquin)
Plesmanlaan 125, 1066 CX, Amsterdam
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