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Are you interested in unravelling rules of life in a dynamic environment? Join our team!
Cells live in a continuously changing (dynamic) and noisy environment. It is fascinating how cells respond to relevant changes in their environment while staying ignorant of the noise. Protein-kinases play a central role in transmitting the relevant 'input signals' throughout the cell, catalysing or inhibiting chemical reactions, thereby forming a connected network of intracellular signalling.
The revolutionary single-cell technologies now allow us to sample thousands of cells for their molecular composition. Our team focuses on adapting these technologies to study how cells process dynamic input signals, and what happens to cells' ability to interpret these signals in case of disease or drug pressure. For this position, you will join a multidisciplinary team that aims to unravel the rules of 'molecular information processing'. As a member of the group, which includes chemists, molecular biologists, microfluidics engineers and computational scientists, you will initially work on the design of dynamic cell environments and use computational tools to analyse single-cell multi-omics datasets. In close collaboration with wet-lab scientists, you will design and perform cell biology experiments to generate multi-omics datasets that contain information on cell signalling state. Ultimately, you will study the information flow throughout the cellular signalling network in response to custom-designed dynamic input signals. Throughout the project, you will work with mathematical modelling techniques, bioinformatics, and will have the opportunity to work with or help to improve the design and analysis tools of experiments based on microfluidics, molecular biology and single-cell technologies.
Fixed-term contract: You will be appointed for an initial period of 18 months, after which your performance will be evaluated. If the evaluation is positive, the contract will be extended by 2.5 years.
We want to get the best out of science, others and ourselves. Why? Because this is what the world around us desperately needs. Leading research and education make an indispensable contribution to a healthy, free world with equal opportunities for all. This is what unites the more than 22,000 students and 5,000 employees at Radboud University. And this requires even more talent, collaboration and lifelong learning. You have a part to play!
As a PhD Candidate, you will be part of the Physical-Organic Chemistry group at Radboud University (Nijmegen, Netherlands). The group is part of Theme 2, Chemistry of Complex Systems, of the Institute for Molecules and Materials (IMM).
The IMM is an interdisciplinary research institute in chemistry and physics at Radboud University. IMM's mission is to perform fundamental research to understand, design and control the functioning of molecules and materials and to train the next generation of leaders in science and entrepreneurship to the highest international standards. You will have the opportunity to interact with researchers at the IMM and participate in institute-wide activities.
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