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The project
Glycosylation is the most abundant post-translational modification of proteins, whereby each pathogen or tumor cell carries a specific sugar pattern (the “sugar code”). Our research centers on how the immune system deciphers the glyco-code by employing glycan-binding C-type lectin receptors to adjust and fine-tune immune responses. We aim to investigate how different ligands induce C-type lectin signaling and how this affects dendritic cell biology. Moreover, we will employ a powerful high-throughput method to identify and develop small glycosylated macrocyclic peptides that target C-type lectins, in order to identify molecules that can eventually be used to activate or dampen immune activity. This project is funded by the Dutch Research Council (NWO) and is a joint collaboration between the research groups of dr. S.J. van Vliet (Amsterdam UMC/VUMC) and dr. S. Jongkees (Utrecht University).
Your Challenge
Your main tasks and responsibilities will be:
For the group of dr. S.J. van Vliet, we are looking for a highly motivated and enthusiastic PhD student with the following qualities and requirements:
Fixed-term contract: 12 months.
Salary Scale PHD: 2422 tot 3103 euro gross when employed full-time (depending on qualifications and experience).
In addition we offer:
We offer an initial contract for 12 months that can be extended (after evaluation) for another 36 months.
For more information about our employment conditions, please visit our website.
For Dutch citizens it is mandatory to provide a VOG (Verklaring Omtrent Gedrag).
The research will be performed within the group of dr. S.J. van Vliet in the Department of Molecular Cell Biology and Immunology at Amsterdam UMC (location VUmc; within the O|2 Lab Building located near the hospital). You will work in a team with young and enthusiastic researchers, who have expertise in immunology, oncology, biochemistry and cell biology. Research within the department of Molecular Cell Biology and Immunology is performed in a stimulating environment and at an international high competitive level. The department consists of several research groups that study immunological processes at cellular and molecular level in health and disease.
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