For a project that aims to uncover the proximal intracellular signaling events of the myeloid inhibitory immunoreceptor SIRPa by advanced microscopic techniques, we are looking for a postdoctoral fellow.
You will join the group of prof. dr. Timo K. van den Berg that is focusing on the role of innate immune cells in immunotherapy of cancer and other diseases. Our laboratory was among the pioneering ones discovering that the interaction between CD47 expressed on cancer cells and SIRPa on phagocytes functions as an innate immune checkpoint that upon disruption can promote antibody-mediated destruction of cancer cells (Zhao XW et al. (2011) PNAS 108:18342–18347). With encouraging results from the first clinical trials using therapeutic agents targeting CD47-SIRPa in recent years this has now become one of the most exciting and rapidly expanding fields in cancer immunotherapy. You will work in a dynamic environment where both fundamental and translational research related to immunotherapy is being performed.

• enthusiastic and motivated researcher with a PhD in cell biology, immunology, and/or oncology. 
• ample experience with cellular and molecular techniques, in particular advanced microscopic methods (such as FRET or FLIM).
• team player with excellent communication skills, also in English.

Fixed-term contract: 3 years.

Our offer

• challenging and clinically relevant project funded by the Dutch Cancer Foundation KWF; 
• temporal position for 3 years; 
• salary and conditions according to CAO Sanquin;
• 8,33% end-of-year bonus; 
• 8,33% holiday allowance; 
• 201 hours of leave with fulltime employment (36 hours);
• partial reimbursement of travel expenses;
• pension plan with Pensioenfonds Zorg & Welzijn (PFZW);
• collective agreement with various insurance companies;
• a multiple-choice system that enables employees to select their own preferred terms of employment;
• fulltime employment (36 hours).

Sanquin

Sanquin is responsible for safe and efficient blood supply in the Netherlands on a not-for-profit basis. Sanquin also develops and produces pharmaceutical products, conducts high-quality scientific research, and develops and performs a multitude of diagnostic services.