An ambitious experimental biologist to join us. You will contribute to the deep understanding of gene regulation and cell fate determination governing corneal (limbal) stem cells in health and in a rare eye disease (aniridia).

You will be using human/patient limbal stem cell models, involving both primary cells and cells derived from induced pluripotent stem cells. You will perform state-of-the-art multi-omics analyses, especially at the single-cell level, to address fundamental and translational questions on stem cell biology, disease mechanisms, drug discovery and mechanism of action. You will also have the opportunity to develop novel ideas and projects that align with this research theme. As part of an EU-funded project, you will work with an international interdisciplinary team covering a wide range of disciplines from clinical ophthalmology to drug discovery.

• PhD in molecular/cellular biology or a related field.
• Demonstrated experience in stem cell work, preferably in (induced) pluripotent stem cell culture and differentiation.
• Demonstrated experience in molecular and cellular analyses (e.g., cloning, RT-qPCR and protein immunofluorescence and western blotting analyses).
• Affinity for systems biology approaches (e.g., RNA-, ChIP-, ATAC-seq, proteomics, or single-cell transcriptomic approaches).
• Strong analytical skills and result-oriented attitude.
• Fluent in written and spoken English; grant writing experience is preferred.
• Team player with strong social skills and the ability to communicate effectively with different research partners.

Fixed-term contract: 2 years.

• Employment: 0.8 - 1.0 FTE.
• A maximum gross monthly salary of € 4,402 based on a 38-hour working week (salary scale 10).
• The exact salary depends on the candidate's qualifications and amount of relevant professional experience.
• In addition to the salary: an 8% holiday allowance and an 8.3% end-of-year bonus.
• Duration of the contract: 2 years.
• The intended start date is 1 June 2021.
• You will be able to use our Dual Career and Family Care Services. Our Dual Career and Family Care Officer can assist you with family-related support, help your partner or spouse prepare for the local labour market, provide customized support in their search for employment  and help your family settle in Nijmegen.
• Have a look at our excellent employment conditions. They include a good work-life balance (among other things because of the excellent leave arrangements), opportunities for development and a great pension scheme.

We want to get the best out of science, others and ourselves. Why? Because this is what the world around us desperately needs. Leading research and education make an indispensable contribution to a healthy, free world with equal opportunities for all. This is what unites the more than 22,000 students and 5,000 employees at Radboud University. And this requires even more talent, collaboration and lifelong learning. You have a part to play!

Faculty of Science

We are a collaborative institute at the Radboud Institute for Molecular Life Sciences (RIMLS), Faculty of Science, Radboud University (Nijmegen, Netherlands), consisting of the departments of Molecular Biology, Molecular Developmental Biology and Cell Biology. The overarching research theme of our institute aims at understanding gene regulation and epigenetics in health and disease using state-of-the-art genomics, single-cell analysis, proteomic technologies and bioinformatics. We offer a first-class international and multicultural research environment and opportunities for personal development. We encourage female researchers to apply, and offer tailor-made mentoring programmes.

You will join Dr Jo Huiqing Zhou's research group, which focuses on gene regulation and cell fate determination in epithelial biology and related diseases using human stem cell models. Her team is characterised by dynamic collaborations between members of the group, with other groups at the institute, and also internationally.