Implant-associated infections are a worldwide problem with substantial clinical morbidity and mortality, and economic burden. They are mainly caused by biofilms on implants formed by bacteria Staphylococci (e.g., Staphylococcus aureus). Various chemical and/or physical based techniques have been proposed to prevent this. Physical based techniques, inspired by the nano-scale protrusions found in the wings of flying insects (nature-inspired nanopatterns), have been applied with varying success to kill bacteria (i.e., between 22% and 76%). It was recently shown that an external force is required to efficiently kill bacteria attaching to nanopatterns and biofilm formation on flat surfaces can be controlled with the use of acoustic waves. It is not known whether nature-inspired nanopatterns can effectively be excited using ultrasound (or by other means), and their bactericidal properties can be improved by letting them vibrate.

It is expected that you study the feasibility of using vibrant nanopatterns to effectively kill bacteria by completing the following tasks:

• Develop computational models to study how bacteria would interact with vibrating nanopatterns.
• Design experimental setup and perform experimental research to validate computational models, and to study the feasibility of using vibrant nanopatterns to efficiently kill bacteria.
• Engage in the writing of scientific articles and proposals.

The vacant position is in the Department of Biomechanical Engineering of the 3mE faculty. The project will be performed in close collaboration with the Department of Precision and Microsystems Engineering (PME) of the 3mE faculty, which focuses on developing knowledge and methods for small, innovative, high-precision devices and systems.

We are looking for a candidate with the following qualifications, knowledge and skills:

• a doctorate degree (PhD) in engineering or physics;
• a strong interest in computational and experimental work;
• an interest in bacterial biomechanics and mechanosensing;
• good communication skills and high motivation for teamwork;
• good academic writing and presentation skills in English.

Fixed-term contract: 1 year.

Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities (salary indication € 3.491 - € 4.402 per month). The TU Delft offers a customisable compensation package, a discount on health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged.

For international applicants we offer the Coming to Delft Service and Partner Career Advice to assist you with your relocation. An International Children's Centre offers childcare and there is an international primary school.

This postdoc position has a fixed-term contract of 1 year.

Delft University of Technology

Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context. At TU Delft we embrace diversity and aim to be as inclusive as possible (see our Code of Conduct). Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale.

Challenge. Change. Impact! 

Faculty Mechanical, Maritime and Materials Engineering

The Faculty of 3mE carries out pioneering research, leading to new fundamental insights and challenging applications in the field of mechanical engineering. From large-scale energy storage, medical instruments, control technology and robotics to smart materials, nanoscale structures and autonomous ships. The foundations and results of this research are reflected in outstanding, contemporary education, inspiring students and PhD candidates to become socially engaged and responsible engineers and scientists. The faculty of 3mE is a dynamic and innovative faculty with an international scope and high-tech lab facilities. Research and education focus on the design, manufacture, application and modification of products, materials, processes and mechanical devices, contributing to the development and growth of a sustainable society, as well as prosperity and welfare.

Click here to go to the website of the Faculty of Mechanical, Maritime and Materials Engineering. Do you want to experience working at our faculty? This video will introduce you to some of our researchers and their work.