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Fixed-term contract: you will be appointed for an initial period of 18 months, after which your performance will be evaluated. If the evaluation is positive, the contract will be extended by 2.5 years (4 year contract) or 3.5 years (5 year contract).
We want to get the best out of science, others and ourselves. Why? Because this is what the world around us desperately needs. Leading research and education make an indispensable contribution to a healthy, free world with equal opportunities for all. This is what unites the more than 22,000 students and 5,000 employees at Radboud University. And this requires even more talent, collaboration and lifelong learning. You have a part to play!
In our ERC Synergy Grant funded project HiSCORE - Highly Informative Drug Screening by Overcoming NMR Restrictions, we seek to advance hyperpolarisation, miniaturisation, parallelisation and spin dynamics, and combine these research themes for highly informative drug discovery using nuclear magnetic resonance. We believe that, eventually, magnetic resonance can provide an in-depth biophysical characterisation of drug candidates in a much shorter time than today and will become a very effective platform for rapid drug discovery. This highly interdisciplinary project is run by four laboratories (Geoffrey Bodenhausen, Arno Kentgens, Jan Korvink, and Benno Meier) in three institutions (ENS Paris, Radboud University Nijmegen and the Karlsruhe Institute of Technology).
Magnetic Resonance Research Center
The Magnetic Resonance Research Center (MRRC) at Radboud University focuses on the development of hyperpolarisation methodology in a microfluidic context, including advanced sample handling and use of solvents such as supercritical CO2. We explore Overhauser DNP, rapid-melt DNP and parahydrogen induced polarisation, aiming at a generic approach for hyperpolarising drug candidates. Further research will include the development of parallel NMR detectors and methods to run experiments independently in each detector. Our lab is part of the Dutch national NMR facility and houses a range of state-of-the-art NMR spectrometers ranging from 300 - 950 MHz. For the HiSCORE project, a dedicated 400 MHz WB spectrometer equipped with a 263 GHz CW oscillator is available. Furthermore, the hyphenation of superfluidic chromatography and NMR will be further developed at 950 MHz. The group has unique expertise in the development of miniaturised NMR probe technology.
You will be appointed as a PhD candidate at the Institute for Molecules and Materials (IMM). This institute is one of the major research institutes of the Faculty of Science at Radboud University. IMM is a research institute in chemistry and physics fostering interdisciplinary research. Its mission is to design and create functional molecules and materials with the intention of fundamentally understanding their behaviour.
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