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Are you a bioinformatician interested in learning more about the genetics that enable individuals to live past 100 years old? What makes others vulnerable to Alzheimer's Disease? Do you want to work with long-read sequencing technologies and use computational expertise to unravel rich datasets?
As Ph.D. researcher, you will help unravel a unique long-read genomics dataset of Centenarians (cognitively healthy individuals older than 100 years of age) and Alzheimer’s disease patients.
It is clear that genetic elements are involved with both the increased risk of Alzheimer’s Disease and with the escape of Alzheimer’s Disease, but it is not yet clear which elements are involved. In the AD-REPEAT project, you will investigate the role of large structural genomic variations using Pacbio SMRT long-read sequencing data from hundreds of genomes from well-phenotyped Alzheimer’s Disease patients and cognitively healthy centenarians from the 100-plus Study cohort. This is a unique dataset that represents the extreme ends of the cognitive spectrum, enabling you to maximize the effect size of your analysis. Further, you will also investigate the somatic differences between centenarian blood and brain samples.
We are looking for a PhD for four years to analyze these novel, exciting and rich datasets. You will employ both reference-based and de-novo assembly approaches in order to quantify and analyze the variability of structural variants in the human genome. Our research aim is to:
What will be your responsibilities?
The research area of interest is rapidly growing, and there is no standard analysis pipeline or method, so your creativity will be essential. Within this project most communication will be in English, so fluency in English and excellent communication and organizational skills are essential.
Fixed-term contract: 12 months, to be extended for another 36 months upon evaluation.
We offer a four year PhD contract (starting for 12 months, to be extended for another 36 months upon evaluation). The salary scale starts according to PhD guidelines at € 2495,- in the first year, growing to € 3196,- in the last year (based on a 36 hour contract).
For more information about our employment conditions, please visit our website.
A reference check can be part of the selection procedure. In addition, applying for a VOG (Certificate of Good Conduct) is mandatory for every new employee. The application for a VOG is started from Amsterdam UMC as soon as the new employee has been appointed.
The Academic Medical Center (AMC) and the VU University Medical Center (VUmc) today joined forces in an administrative merger. The chairmen of both Boards of Directors signed the merger into force this afternoon. The signing ceremony took place in downtown Amsterdam, in a fitting location overflowing with Dutch medical history: the 17th century Anatomy Theater in a traditional weighing house called De Waag.
Following an intensive multi-year planning process, the two Amsterdam academic hospitals are working together as of this moment under a collective name: Amsterdam UMC. This enables both Amsterdam university medical centers to further develop their core business together: complex patient care, scientific research, and education & training. Amsterdam UMC kickstarts a gradual process of continuous integration. Initially, this will be most visible in two sectors: patient care and scientific research.
Our lab is based at the department of Human Genetics and the Alzheimer Center at the Amsterdam University Medical Center. This projec is a collaboration with PacBio and with the Delft Bioinformatics Lab at the Technical University in Delft. See also: www.holstegelab.eu.
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