The Bokinsky lab within TU Delft’s Faculty of Applied Science Bionanoscience Department is looking for a new colleague.

In this role you will:

• apply and develop protocols for metabolite quantification and targeted proteomics using LC/MS.
• Train other researchers in the use of established protocols.
• develop new extraction and analysis protocols for both metabolites and proteins in close cooperation with other researchers. (Analysis requirements include lipids, peptides, nucleotides, and other bacterial secondary metabolites.)
• ensure smooth operations in lab and optimal availability of the Agilent 6460 you are responsible for the maintenance.

If you want to pursue independent research within the scope of the department’s overall goals we will certainly look at the possibilities.

• First and foremost we expect you to have experience with a triple quadrupole LC/MS and HPLC.
• A (Master or PhD) degree in a biological or chemical discipline is essential.
• A record of accomplishments using chromatographic methods and mass spectrometry to analyse complex biological systems is also essential.
• Proficiency with data analysis software (e.g. Skyline) and the Python programming language is highly desirable but not necessary.
• Since you will be working in an environment with international students and scientists, good communication skills in English are essential.

This is a position for two years, further extension depending on funding.

Depending on experience and level of education your salary can range  from 3,270 € gross/month to 4,474 € gross/month (for 1 fte)

The salary is according to the Collective Labour Agreement of the Dutch Universities, plus 8%  holiday allowance and an end-of-year bonus of 8.3%.

You will be employed according to the Collective Labour Agreement of the Dutch Universities which includes an excellent pension scheme via the ABP and 232 leave hours (at 38 hours).

As part of the individual employment package that TU Delft offers you can also sell or buy additional leave hours and make other arrangements.

Delft University of Technology

Delft University of Technology is built on strong foundations. As creators of world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context. At TU Delft we embrace diversity and aim to be as inclusive as possible (see our Code of Conduct). Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale.

Challenge. Change. Impact! 

Department

With more than 1,000 employees, including 135 pioneering principal investigators, as well as a population of about 3,400 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. To that end, we train students in broad Bachelor's and specialist Master's programmes with a strong research component. Our scientists conduct ground-breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics. We are also training the next generation of high school teachers and science communicators.

The Department of Bionanoscience focuses on the fundamental understanding of biological processes, from the level of single molecules to the full complexity of living cells. This research provides fascinating insight in the molecular mechanisms that lead to cellular function. Furthermore it enables the in vitro bottom-up construction of cellular machinery and it impacts applications ranging from biomolecular diagnostics to novel antibiotics and targeted nanomedicine. The department features a strongly multidisciplinary and international team of scientists, whose research areas include single-molecule biophysics, synthetic biology, as well as (quantitative) cell biology.

Researchers within the Department use LC/MS for applications ranging from engineering antibiotic synthesis in bacteria (described here: https://www.nature.com/articles/s41589-018-0084-6 ) to building artificial life (https://www.nature.com/articles/s41467-020-17863-5 ). One of our novel LCMS methods that combines features of targeted proteomics with metabolomics is described here: pubmed.ncbi.nlm.nih.gov/27595277. This method was used to discover control points in a metabolic pathway (described here: journals.asm.org/doi/10.1128/mBio.02703-19).