The project
In this project you will perform preclinical studies on perivascular spaces of the rodent brain using 2-photon microscopy and other techniques. You will investigate the anatomy of perivascular spaces and elucidate the driving forces for clearance in this system. These could be cardiac pulsations, breathing, or vascular contractions. Particular interest will be directed to the role of sleep, which may promote clearance through currently unknown mechanisms.

About your role
Several types of dementia are characterized by accumulation of toxic waste products. At present, it is not clear how waste is removed from the brain and how this fails in disease. However, there is recent evidence that perivascular spaces may contribute to brain clearance. These spaces are unique for the brain and may facilitate waste clearance most effectively during sleep.

• A master of science degree in Biomedical Sciences, Biology, Neuroscience, Cardiovascular sciences, or similar.
• Experience with experimental research in the field of neurology or the cardiovascular system is an advantage.
• Experience with microscopy is an advantage.

Fixed-term contract: a 4-year (PhD) contract starting with 12 months, which will be extended to another 36 months when positively evaluated.

• We offer training in a PhD trainee program and create opportunities for career development PhD Safety Net infographic (amsterdamumc.org)
• We offer a 4-year (PhD) contract starting with 12 months, which will be extended to another 36 months when positively evaluated.
• We offer further training in a PhD trainee program and create opportunities for career development.
• The salary is conforming the CAO-UMC’s, starting at € 2.570 on a full-time basis in year one, increasing towards € 3.271 in the 4th year.
• In addition to a good basic salary, we offer an 8.3% year-end bonus and 8% holiday pay.
• Your pension is built up with ABP; the Amsterdam UMC contributes a large part of the premium (70%).
• Besides excellent accessibility by public transport, we reimburse 75% of your public transport costs and have a lucrative bicycle-plan.

Bekijk alle arbeidsvoorwaarden bij AMR

Amsterdam UMC

Working at  Amsterdam UMC takes place in an inspiring and professional environment where development in every form is encouraged. 

You will work in an enthusiastic team of researchers who share their interest for the cerebrovascular system. We study stroke, micro-infarcts, hypertension, and perivascular spaces using cutting edge technology such as 2-photon imaging, MRI, ultrasound, and an in house developed imaging cryomicrotome setup.

The project is part of a collaborative effort with Leiden University Medical Center, where a human counterpart of the current project is carried out. This provides a true translational framework that is expected to increase the impact of the project.