Gene regulation a major driving force in development and differentiation. Therefore, faulty gene regulation lies at the heart of the majority of diseases. Intracellular signaling coordinates cell behavior and cell identity by directly regulating gene expression and constitutive signaling leads to cancer. So far understanding of the molecular mechanisms that lead to signaling-driven cancer formation are poorly understood. The recent discovery of signaling condensates ("protein droplets") tells us that these have might an important function in signaling driven-gene regulation. The Post Doc will develop a new condensate imaging technology into a high throughput screening platform for condensate perturbing compounds to combat cancer using state-of-the-art live cell imaging, genome engineering and organoid culturing approaches.

We are looking for a highly motivated and skilled Post Doc with an interest/background in molecular and transcriptional biology. The ideal candidate is self-motivated, detail-oriented, and collaborative. A good ability to think critically is expected.

For more information feel free to contact Dr. Jurian Schuijers. Please send applications including your CV with a letter of motivation, a list of publications, and contact details of at least two references.

The maximum salary for this position (36 - 36 hours) is € 4.707,00 gross per month based on full-time employment.

In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses and career opportunities. The terms of employment are in accordance with the Cao University Medical Centers (UMC).

The candidate will be appointed in the UMC Utrecht Center for Molecular Medicine in the group of Dr. Jurian Schuijers. A major focus of the CMM is understanding the molecular mechanisms of cancer. The Schuijers group focusses on biomolecular condensates in transcription using WNT-driven colon cancer as primary model system, and has a strong background in genomics, development of live-cell imaging techniques, genome engineering, (patient derived) organoids and biochemistry.