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To gain insights into the pathophysiological mechanisms of VITT/TTS, you will have the unique opportunity to investigate several interesting hypotheses regarding the vaccine-induced cellular responses using adenoviral vectors and spike proteins and their immunological effects on presumed key cellular players platelets, endothelial cells and monocytes. Cellular activation markers, secreted pathogenic factors and immunological pathways will be investigated. In this postdoc position you will work in close collaboration with a research technician with the goal to shed light on this clinically important and timely problem from a laboratory perspective.
Research group and institute
You will work in a research group within the department of Experimental Immunohematology at Sanquin in Amsterdam. Sanquin is a knowledge-driven, not-for-profit organization that supplies life-saving products and services, and is involved in cutting-edge research related to blood transfusion medicine and immunology. The different lines of research are strategically aligned with Sanquin’s mission to provide mechanistic insight into and develop novel therapeutic approaches for blood-related disorders. Furthermore, the highly dynamic research-environment is composed of research group leaders and many postdocs, PhD students and technicians. In addition, Sanquin harbors the national referral center for diagnostics for several immune-mediated disorders including VITT/TTS. This research project will be carried out with support from and in collaboration with Janssen Vaccines & Prevention B.V.
Fixed-term contract: 1 year with possibility of extension for a 2nd year.
Sanquin Blood Supply Foundation (Sanquin)
Plesmanlaan 125, 1066 CX, Amsterdam
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