ScreeninC is a KWF-funded national infrastructure that supports CRISPR functional screens for cancer researchers. ScreeninC is a collaboration between the iPSC/CRISPR centre at ERIBA (Prof. Floris Foijer), the Netherlands Cancer Institute in Amsterdam (Prof. Roderick Beijersbergen) and Leiden University (prof. Bob van de Water). ScreeninC provides expertise, tools, service and infrastructure for functional genomic screens ranging from advanced model generation using CRISPR/Cas9 to large scale CRISPR screening. The three sites hosting ScreeninC (Groningen, Amsterdam and Leiden) closely work together in the development and implementation of new technologies for genome editing and screening and provide support for CRISPR screening projects to research groups in the Netherlands.

You will become part of the ScreeninC team and be based at the iPSC/CRISPR centre at the University Medical Center in Groningen. You will closely work with your colleagues of the iPSC/CRISPR centre, the Foijer lab, the Netherlands Cancer Institute and Leiden University. You will assist researchers who reach out to ScreeninC with optimization and execution of their CRISPR screens and furthermore be responsible for implementing CRISPR screens in complex model systems including organoids and iPSCs. Finally, you will reach out to (cancer) researchers throughout the Netherlands to inform them about the possibilities of CRISPR screens and how ScreeninC supports these.

- A PhD in bio-molecular sciences, medical biology, or a related area.
- Ample experience with CRISPR genome engineering is a big plus.
- Affinity/experience with complex culture systems (iPSCs, organoids) is also a plus.
- You have an inquisitive and independent attitude.
- You have excellent communication skills and are a team player.
- You have excellent entrepreneurial skills.

The UMCG has a preventive Hepatitis B policy. The UMCG can provide you with the vaccination, should it be required for your position.

In case of specific professions a ‘Certificate of Good Conduct’ is required.

The position is for up to 27 months, with an initial trial period of 1 year (36 hours a week). Your salary will be a maximum of € 4.800,- gross per month (scale 10), depending on your qualifications and relevant experience, based on a full-time appointment. In addition, the UMCG will offer you 8% holiday pay, and 8.3% end-of-year bonus. The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).

More information
Information about the Foijer lab
Information about ERIBA
Information about Groningen

ERIBA

The European Research Institute for the Biology of Aging (ERIBA) is a research institute at the University Medical Centre Groningen (UMCG), in Groningen, the Netherlands. The mission of ERIBA is to better understand the molecular mechanisms that result in age-related decline and age-related diseases. The iPSC/CRISPR centre at ERIBA is one of the UMCG research support infrastructures. The facility serves as an expertise centre and education hub for iPSC and CRISPR-related techniques for the University of Groningen and UMCG. The facility generates and genetically engineers induced pluripotent stem cells (iPSCs) and their differentiated progeny for university and UMCG employees. Furthemore, the iPSC/CRISPR centre helps end-users to genetically engineer primary cells and cell lines using CRISPR/Cas9 technology and to perform functional genetic screens using CRISPR libraries.

ERIBA is part of the central UMCG campus in the vibrant university city Groningen in the north of the Netherlands.