Postdoc 'Novel immunotherapeutic targeting of B cell malignancies and effects on neutrophils'

Postdoc 'Novel immunotherapeutic targeting of B cell malignancies and effects on neutrophils'

Published Deadline Location
27 Jul 6 Sep Nijmegen

Job description

In this project, we will study novel CD37 antibodies (''hexabodies'') in their cytotoxic capacity in human lymphomas. Secondly, we aim to identify the underlying molecular mechanism by investigating downstream signaling and CD37 organization at the cell surface of lymphomas and primary immune cells (neutrophils) using advanced microscopy techniques. Will you join our team?

Tetraspanins belong to the transmembrane-4-superfamily that consists of small (20-50 kDa) transmembrane proteins that are abundantly expressed at the cell surface. We discovered that the B cell-specific tetraspanin CD37 is a novel tumor suppressor in lymphoma (de Winde et al. J. Clin.Invest. 2016, Elfrink et al. Blood 2019, Peeters et al. In Press 2022).

Targeting CD37 is currently under clinical investigation in patients with aggressive lymphomas (de Winde et al. Trends in Cancer 2017, Oostindie et al., Blood Cancer J. 2020). This project is supported through the ERC (Consolidator Grant) and in collaboration with Genmab.

Specifications

Radboud University Medical Center (Radboudumc)

Requirements

Candidates should have obtained a PhD degree in biology/immunology or equivalent. In this project we will combine immunological (tumor cytotoxicity assays, flow cytometry) with cell biological techniques (migration, advanced cell imaging, signal transduction). An extensive immunological/cell biological background is therefore important.

Conditions of employment

Fixed-term contract: 3 years.

Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. And there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At Radboud university medical center, you will be given trust, and you will take the responsibility to handle everything together. We provide annual courses, both professional and personal.
  • In addition to your monthly salary and an annual vacation allowance of 8%, you will receive an end-of-year bonus of 8.3%.
  • If you work irregular hours, you will receive an allowance.
  • As a full-time employee (36 hours per week), you are entitled to approximately 168 vacation hours (over 23 days) per year.
  • Radboud university medical center pays 70% of the pension premium. You pay the rest of the premium with your gross salary.
  • You get a discount on health insurance as well: you can take advantage of two group health insurance plans. UMC Zorgverzekering and CZ collectief.
In addition to our terms of employment, we also offer employees various other attractive facilities, such as childcare and sports facilities. Want to learn more? Take a look at the CAO UMC.

Employer

Radboudumc

Radboud Institute for Molecular Life Sciences (RIMLS) in the Netherlands is a leading European research school providing an outstanding research setting within the Radboud University Medical Center. The RIMLS focuses on basic science and its translation into pioneering treatments in the clinic. RIMLS innovations are advanced through technology platforms such as genomics, proteomics, and molecular imaging.

Department of Tumor Immunology: Research within the department aims at a better understanding of our immune system using molecular, cell biological and immunological techniques. Our research is centered around dendritic cells, B cells and regulatory T cells which play an important role regulating the immune response. We investigate the interplay between immune and tumor cells within the tumor microenvironment. In addition, we study membrane protein organization at the cell surface of immune cells that is important for signal transduction. An important activity of the department is the translation of basic research into clinical application.

Radboudumc
Radboud university medical center is a university medical center for patient care, scientific research, and education in Nijmegen. Radboud university medical center strives to be at the forefront of shaping the healthcare of the future. We do this in a person-centered and innovative way, and in close collaboration with our network. We want to have a significant impact on healthcare. We want to improve with each passing day, continuously working towards better healthcare, research, and education. And gaining a better understanding of how diseases arise and how we can prevent, treat, and cure them, day in and day out. This way, every patient always receives the best healthcare, now and in the future. Because that is why we do what we do.

Read more about our strategy and what working at Radboud university medical center means. Our colleagues would be happy to tell you about it. #weareradboudumc

Additional information

All additional information about the vacancy can be obtained from Prof. Annemiek van Spriel, research group leader. We invite you to check the website of the Research group - Immune cell signaling. Use the Apply button to submit your application.

Specifications

  • Postdoc
  • Natural sciences; Health
  • max. 36 hours per week
  • €2986—€4707 per month
  • Doctorate
  • 166026-P1026573-1

Employer

Radboud University Medical Center (Radboudumc)

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Location

Geert Grooteplein-Zuid 10, 6525 GA, Nijmegen

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Application procedure

All additional information about the vacancy can be obtained from Prof. Annemiek van Spriel, research group leader. We invite you to check the website of the Research group - Immune cell signaling. Use the Apply button to submit your application.

Application procedure

Application procedure

All additional information about the vacancy can be obtained from Prof. Annemiek van Spriel, research group leader. We invite you to check the website of the Research group - Immune cell signaling. Use the Apply button to submit your application.

Make sure to apply no later than 6 Sep 2022 23:59 (Europe/Amsterdam).