We have multiple vacancies for post-doctoral researchers in neuroimaging and/or genetics to work on the development and application of multivariate statistical analyses to large scale data. The project is part of a large HORIZON Europe consortium aimed at better understanding familial transmission of mental health problems. Will you join our project?The overall focus of the FAMILY Consortium is to better understand the intergenerational transmission of mental health problems, such as mood disorders and psychosis, via multilevel research from the inheritance of the molecular DNA, to the epigenomic and (shared/familial) environmental processes, and systems neuroscience. Our role in this consortium is to integrate genomics and neuroimaging MRI data in ways that allow informative individual (genomic) profiling and (normative/predictive) modelling across different cohorts.
As a postdoc you will apply existing data-driven multivariate statistical techniques (e.g. PCA, ICA) and help develop new analysis pipelines aimed at improved biological interpretation and individual stratification on the basis of genomic data, and structural and functional MRI. The project involves multimodal feature extraction based on very large datasets (UK Biobank, ABCD, Generation R), followed by feature selection and application to smaller, more clinically focused target cohorts. You will be encouraged to make publicly available your new tools and pipelines (e.g on github) to enable other researchers to take advantage of the innovations produced in these projects.
The vacant positions are highly interdisciplinary and integrate machine learning and statistics with neuroimaging, clinical neuroscience and psychiatry. Successful applicants are not required to have experience and knowledge of all disciplines and techniques involved yet. We encourage applications from individuals who have already demonstrated one or more relevant skill and discipline (genetics or neuroimaging or machine learning), and who are motivated to expand their expertise as needed to complete the project. We also highly value an applicant's motivation to help making an impact on mental health.
The project you will be contributing to is a HORIZON Europe consortium project "FAMILY", in close collaboration with partners at Rotterdam Erasmus MC, Leibniz Institute for Resilience Research (Mainz), University College London, Harvard University, and others. The postdoc positions are hosted by the Donders Institute for Brain, Cognition and Behavior at the Radboud University Medical Center (Cognitive Neuroscience department) under the supervision of Dr. Emma Sprooten and Prof. Christian Beckmann, and integrated into the wider academic research environment at the Donders Institute.
Tasks and responsibilities
- Discuss, plan and perform research in a stimulating environment.
- Optimize and apply existing and new multivariate statistical approaches for genomic and neuroimaging analysis.
- Apply these statistical models to large-scale population cohorts and (smaller) clinical family trio datasets.
- Write scientific papers and publish findings in peer-reviewed journals and present at international scientific conferences.
- Make your pipelines and tools publicly available to enable for the use of the wider scientific community.
- Assist with the supervision of (Master) students and more junior staff.
- Work in an interdisciplinary team of international scientists.
- Collaborate with our consortium partners with excellent opportunities to develop and expand academic networks.