We are looking to fill a four-year PhD position in virology at the department of Viroscience Project

Title: Characterization of fusion inhibitory peptides against COVID-19.
Respiratory virus infections are omnipresent, affecting global health and economy. Studies into antiviral treatments against these respiratory virus infections are essential. The most recent example underlining this importance is the COVID-19 pandemic caused by SARS-CoV-2. Together with collaborators in the US, we have designed specific antiviral peptides that can interfere with the fusion between viral membrane and cell membrane, thereby preventing virus infections of cells. In initial proof-of-concept studies, we have shown that these fusion inhibitory peptides can prevent SARS-CoV-2 infection in vitro, and SARS-CoV-2 transmission in animal models. However, improvements to these fusion inhibitory peptides need to be made with regards to (1) solubility, (2) toxicity, (3) stability, and (4) biodistribution, before implementation in a clinical product (like a nasal spray) is likely. In this project, the PhD candidate will help with the design of these improved peptides, and will design and perform experiments to study their functionality in vitro and in vivo. In these studies, the candidate will use a plethora of state-of-the-art techniques, including (primary) cell culture, flow cytometry, comprehensive data-set analysis, multicolor confocal microscopy, immunological assays, and virus culture and animal experiments in a biosafety level (BSL)-3 environment.

• We are looking for a PhD student that is enthusiastic and highly motivated with a MSc degree or equivalent from an accredited academic program in Biology, Biomedical or Molecular Sciences, or (Veterinary) Medicine.
• Demonstrable affinity with the above-mentioned techniques will be beneficial, and the candidate should be willing to work with human tissues, primary cells, and experimental animals in a BSL-3 environment.
• The candidate has an excellent command of the English language, both oral and written.
• Candidate is expected to obtain their PhD in 4 years.

• You will receive a temporary position for 4 years. The gross monthly salary is € 2.631,- in the 1st year and increases to € 3.336,- in the 4th year (scale OIO).
• The terms of employment are according to the Collective Labour Agreement for Dutch University Medical Centers (CAO UMC

Erasmus MC

The Department of Viroscience at Erasmus MC employs more than 150 employees of different disciplines and runs an extensive experimental research program on the epidemiology, pathogenesis, prevention and treatment of infections by human and animal viruses. All necessary equipment to carry out the research proposed in the project is available within the setting of the department. The Department of Viroscience harbors well-equipped clinical and experimental virology labs, in which all the virology, molecular biology and pathology techniques necessary for this project is operational.