Are you a scientist with a PhD degree or close to obtaining a PhD degree in neurobiology or a related field, and interested in a scientific career? Are you passionate about science and a critical and creative thinker? Are you interested in exploring the molecular mechanisms underlying motor neurodegenerative disease and perform cutting-edge biomedical research? Then you have a part to play as a postdoctoral researcher!
We are recruiting an ERC-funded postdoctoral researcher who will work independently on Drosophila genetics projects. Your main project will use reverse genetic approaches to model familial forms of motor neurodegenerative and neuromuscular diseases in Drosophila. You will evaluate the disease-relevance of the obtained knock-in Drosophila models by behavioural analysis, immunohistochemistry (IHC), confocal imaging and in vivo noncanonical amino acid tagging (NCAT) approaches. Finally, for valid disease models, you will dissect the underlying molecular mechanisms of disease using Drosophila genetic approaches complemented with behavioural analysis, IHC, FISH, imaging, molecular biology, biochemistry, and next-generation sequencing. In addition, you will have the opportunity to contribute to other ongoing projects in the lab, for example by studying the molecular pathogenesis of CMT peripheral neuropathy associated with mutations in tRNA synthetases, following up on our recently published work (Zuko, Mallik et al, Science, 2021), or characterising genes identified in a forward genetic screen for genes required for maintenance of peripheral motor and sensory axons (unpublished). You will have the opportunity to collaborate with and supervise Master's students, and in the longer run also PhD candidates. You will get some exposure to teaching in Master's courses. Eventually, the development of an independent research project that can be transferred to a future position is possible and highly encouraged.
Fixed-term contract: It concerns a temporary employment for 2 years with the intention to extend for 2 more years.
Within the Department of Molecular Neurobiology, the Storkebaum lab combines Drosophila and mouse genetics to unravel molecular mechanisms underlying motor neurodegenerative and neuromuscular disorders. Our current focus is on Charcot-Marie-Tooth (CMT) peripheral neuropathy associated with mutations in tRNA synthetases and on amyotrophic lateral sclerosis (ALS) associated with mutations in FUS. More broadly, we are interested in the molecular mechanisms underlying axonal degeneration, with a focus on the role of mRNA translation defects. We use a broad spectrum of methods and techniques including a recently developed method for cell-type-specific in vivo labeling of newly synthesized proteins (NCAT), several high-end imaging techniques (confocal and super-resolution microscopy), single-molecule FISH, (single-cell/single-nucleus) transcriptomics, whole genome sequencing, mouse and Drosophila behavioural analysis, electromyography, histology, immunohistochemistry, molecular biology and biochemistry.
Our dynamic and international team currently consists of two postdocs, four PhD candidates and one technical assistant. In addition, we have strong international collaborations with scientists working on RNA biology and genetics. We attracted substantial external funding, including an ERC Consolidator grant, two JPND grants, and grants from the Radala Foundation for ALS Research, the Muscular Dystrophy Association (MDA), AFM, ARSLA, the Dutch ALS Association, Prinses Beatrix Spierfonds, and the Dutch Research Council (NWO). We have published several papers in high-impact journals, including Science, Nature Neuroscience, Journal of Cell Biology, Nature Communications, Acta Neuropathologica, EMBO Journal and Plos Genetics.
Houtlaan 4, 6525 XZ, Nijmegen
This application process is managed by the employer (Radboud University). Please contact the employer for questions regarding your application.
Please contact the employer for questions regarding your application.
Tip: save this job as favorite in your AcademicTransfer account. This gives you an immediate overview and makes it easy to find the job later on. No account yet? Create it now and take advantage of other useful functionalities too!
Make sure to apply no later than 30 Nov 2022 23:59 (Europe/Amsterdam).
We like to make it easy for you, sign in for these and other useful features: