Postdoc position in the field of single-molecule biophysics

Postdoc position in the field of single-molecule biophysics

Published Deadline Location
16 Nov 28 Feb Amsterdam

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Do you have experience in the biophysics of protein-nucleic acid interactions? Are you interested in interdisciplinary research at the frontier of physics, biology and chemistry? Please apply at Vrije Universiteit Amsterdam (VU).

Job description

The Dulin lab at VU has to offer one fully funded postdoc position (1+2 years) in the field of biophysics to study protein-nucleic acids interactions to start as soon as possible. The successful candidate will have the opportunity to investigate protein-RNA interactions, with a particular focus on RNA virus's replication-transcription complex, e.g. SARS-CoV-2, dengue, chikungunya, using state-of-the-art single molecule techniques, e.g., magnetic tweezers (MT), total internal reflection fluorescence microscopy (TIRFM), correlative MT-TIRFM, single-molecule FRET, combined optical tweezers and fluorescence microscopy. Specifically, our lab aims at reconstituting the viral replication-transcription complex in vitro for the aforementioned viruses. We will use a combination of force and fluorescence spectroscopy to investigate how the composition of these complexes regulate their function. Our long-term goal is to discover new drug antiviral targets. Within the lab, the successful candidate will design and perform experiments, and develop new computational analysis tools to perform these investigations.


Vrije Universiteit Amsterdam (VU)


We are seeking for
  • An outstanding experimentalist with experience in biophysics, biotechnology, physics, and/or enzymology. Experience in optics, computer programming (LabVIEW, Python, Matlab, C++, etc.) and/or quantitative investigation of protein-nucleic acids interactions.
  • A creative and hard-working individual with strong work ethic, interest in crossing research fields, and very collaborative.
Our future colleague will successfully develop and combine different expertise's in physics, biology and software programming to understand the fundamental steps in viral genome replication and transcription. Proficiency in English (both speaking and writing) is required.

Conditions of employment

Fixed-term contract: 1 year.

A challenging position in a socially involved organisation. On full-time basis the remuneration amounts to a minimum gross monthly salary of €2,960 (scale 10) and a maximum €4,670 (scale 10), depending on your education and experience. The job profile Researcher 4 (Onderzoeker 4) is based on the university job ranking system and is vacant for at least 0.8 FTE.

The initial employment contract will initially be a period of 1 year. After a satisfactory evaluation of the initial appointment, the contract will be extended (with two years) for a total duration of 3 years.
Additionally, Vrije Universiteit Amsterdam offers excellent fringe benefits and various schemes and regulations to promote a good work/life balance, such as:
  • a maximum of 41 days of annual leave based on full-time employment
  • 8% holiday allowance and 8.3% end-of-year bonus
  • solid pension scheme (ABP)
  • contribution to commuting expenses
  • optional model for designing a personalised benefits package


Vrije Universiteit Amsterdam

The ambition of Vrije Universiteit Amsterdam is clear: to contribute to a better world through outstanding education and ground-breaking research. We strive to be a university where personal development and commitment to society play a leading role. A university where people from different disciplines and backgrounds collaborate to achieve innovations and to generate new knowledge. Our teaching and research encompass the entire spectrum of academic endeavor - from the humanities, the social sciences and the natural sciences through to the life sciences and the medical sciences.

Vrije Universiteit Amsterdam is home to more than 30,000 students. We employ over 5,500 individuals. The VU campus is easily accessible and located in the heart of Amsterdam's Zuidas district, a truly inspiring environment for teaching and research.

We are an inclusive university community. Diversity is one of our most important values. We believe that engaging in international activities and welcoming students and staff from a wide variety of backgrounds enhances the quality of our education and research. We are always looking for people who can enrich our world with their own unique perspectives and experiences.

The Faculty of Science
The Faculty of Science inspires researchers and students to find sustainable solutions for complex societal issues. From forest fires to big data, from obesity to medicines and from molecules to the moon: our teaching and research programmes cover the full spectrum of the natural sciences. We share knowledge and experience with leading research institutes and industries, both here in the Netherlands and abroad.

Working at the Faculty of Science means working with students, PhD candidates and researchers, all with a clear focus on their field and a broad view of the world. We employ more than 1,250 staff members, and we are home to more than 11,000 students.


The Dulin lab is located at VU Amsterdam (, which is one of the best universities in the Netherlands, located in the vibrant and international city of Amsterdam. Our team is an inclusive and diverse group of scientists, welcoming excellent researchers from all backgrounds. We are embedded within the Physics of Living System Section of the Physics Department of VU, together with several other biophysics labs, constituting a unique environment worldwide to investigate the physics of life, and specifically at the single-molecule level. The Dulin lab has a strong expertise in investigating RNA virus genome synthesis molecular complexes using single molecule biophysics techniques, with several breakthrough studies on SARS-CoV-2 genome replication and antiviral drugs evaluation (Bera et al., Cell Reports 2021; Seifert et al., eLife 2021) and transcription (Dulin et al., Nature Communications 2018, Bera et al., NAR 2022). The successful candidates will join an enthusiastic and international team of biophysicists and biochemists ready to tackle highly challenging problems related to antiviral drug discoveries. They will have access to a large variety of cutting-edge assays in single molecule force and fluorescence spectroscopy techniques (e.g., magnetic and optical tweezers, TIRF microscope…), and a molecular biology facility to perform their research. They will also benefit from the support of an experienced staff in molecular biology, biochemistry and data analysis. They will have the opportunity to learn from the best scientists in the field, publish in high-impact journals and present their work in international conferences.


  • Postdoc
  • 30.4—38 hours per week
  • €2960—€4670 per month
  • Doctorate
  • 13182


Vrije Universiteit Amsterdam (VU)

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De Boelelaan 1105, 1081HV, Amsterdam

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