The Analytical Biochemistry (AB) group is looking for an experienced technician in the field of analytical chemistry who is particularly acquainted with mass spectrometry (MS). The AB research group is part of the Groningen Research Institute of Pharmacy (GRIP) and is a dynamic, multidisciplinary group of researchers stemming from the fields of (computational) MS, proteomics and metabolomics. AB is housed in the ERIBA building at the UMCG campus and embeds the Interfaculty Mass Spectrometry Center (IMSC), which is a joint research facility of GRIP and UMCG. AB and IMSC share a well-equipped laboratory with 15 high-end mass spectrometers, primarily hyphenated with LC platforms. There is a well-equipped research infrastructure in place to perform MS-based proteomics and metabolomics, including sample preparation, handling and the analysis of MS data. AB participates in many interdisciplinary research projects, ranging from a fundamental towards a clinical perspective, with a specific focus on biomarker discovery and validation. The AB group has workflows in place to enable the analysis of data from various omics fields such as proteomics, phosphoproteomics, lipidomics and metabolomics, use a variety of mass spectrometry based technological platforms (LC-MS and mass spectrometry imaging) and investigate a wide variety of samples such as different types of cancer tissue, lung tissue, microbiological samples, blood and urine.

The technician will be employed at AB under supervision of Prof. Peter Horvatovich and will support the work of various principal investigators (PI), including a new PI to be hired on the subject of mass spectrometry imaging (MSI) and Dr Guinevere Langeveen-Kammeijer performing research in glycoproteomics and single cell proteomics. Furthermore, the technician will support research activities, infrastructure maintenance, contribute to method development at the IMSC directed by Dr Hjalmar Permentier and will contribute to the development and maintenance of data analysis (ICT) infrastructure of the AB/IMSC.

Key responsibilities

• contribution to the development, implementation and validation of new sample preparation and mass spectrometry analysis methods primarily for MSI and secondly to proteomics/metabolomics LC-MS/MS workflows (single cell proteomics, glycoproteomics, phosphoproteomics)
• contributing to the development and maintenance of data analysis (ICT) infrastructure of AB and IMSC
• performing MSI and LC-MS analyses as well as supporting the reporting of the results
• contributing to the training of bachelor, master and PhD students as well as postdoctoral researchers in MS analysis
• maintaining MSI and LC-MS instruments and solving technical problems.
• contributing to the overall organization of the AB and IMSC laboratory infrastructure.

• a Bachelor’s or Master’s degree in the area of analytical chemistry or a related field
• demonstrable experience with the operation and maintenance of MSI and/or LC-MS equipment and with MSI and/or LC-MS method development
• experience (or willingness to learn) ICT infrastructure maintenance and development (software and hardware)
• good command of oral and written English
• independent, flexible, enterprising, organized, solution-oriented
• affinity with both instrumental techniques, data analysis software and tool scripting
• capable of working in an interdisciplinary, academical, and international environment.

Fixed-term contract: 12 months.

We offer you in accordance with the Collective Labour Agreement for Dutch Universities:

- depending on level of education and experience a salary between € 2,471 and € 4,257 gross per month (scale 7, 8 of 9 according to the collective labour agreements of the Dutch Universities), for a full-time position (1.0 FTE)
- 8% holiday allowance and an 8.3% end-of-year bonus over the gross yearly income
- an appointment for a period of one year, but upon proven suitability for the position, based on a positive assessment after one year, there are prospects of an employment contract for an indefinite period.

Faculty of Science and Engineering

The University of G