2 PhD positions are available in the labs of Debbie van den Berg and Kerstin Wendt at the Department of Cell Biology.

In this project we want to understand the molecular mechanisms behind the neurodevelopmental defects observed in Cornelia de Lange Syndrome and related neurodevelopmental disorders. We will generate brain organoids as well as 2D cell culture models for neuronal differentiation and investigate developmental trajectories, gene expression changes, altered signalling pathways, and binding patterns of gene regulatory proteins. For this we will use a wide range of techniques from NGS approaches (single cell and bulk RNA-sequencing, ChIP-sequencing), proteomics, iPS cell and brain organoid culture, genome editing, biochemistry and imaging. Throughout the project we will intensively collaborate with clinicians and family organisations.

• We are looking for 2 exceptionally talented, highly motivated candidates that hold an MSc degree in Biomedical Science, Nanobiology, Neuroscience or a related field.
• Experience with or willingness to become familiar with bioinformatics analysis in programming languages R and Python is a must.
• You have excellent communication skills in both written and spoken English and like to collaborate.

• You will receive a temporary position for 4 years.
• The gross monthly salary is € 2.789 ,- in the 1st year and increases gradually to € 3.536,- in the 4th year (scale OIO).
• Excellent fringe benefits, such as a 13th month that is already paid out in November and a induvidual travel expense package.
• Pension insurance with ABP. We take care of approximately 2/3 of the monthly contribution.
• Special benefits, such as a incompany physiotherapist and bicycle repairer. And there is also a sports club where you can work on your fitness after work.
• An International Office which aids you in preparing for your arrival and stay.

Erasmus MC

Erasmus MC stands for a healthy population and excellence in healthcare. By conducting groundbreaking work, we aim to push boundaries through leading the way in research, education and healthcare. We have access to the latest equipment and techniques in a state-of-the-art environment.

The Department of Cell Biology is embedded in the dynamic, internationally competitive research community of over 40 biomedical research labs within the Erasmus MC. The main language in the department is English. Core facilities like the Erasmus Center of Genomics, iPS facility, and the Optical Imaging Center will be important collaborators for the project. The successful candidates will join the Erasmus MC Graduate school and follow the Biomedical Sciences PhD track.